The authoritative guide for Data Monitoring Committees—fully revised and updatedThe number of clinical trials sponsored by government agencies and pharmaceutical companies has grown in recent years, prompting an increased need for interim monitoring of data on safety and efficacy. Data Monitoring Committees (DMCs) are an essential component of many clinical trials, safeguarding trial participants and protecting the credibility and validity of the study. Data Mo...

This is the fifth edition of a very successful textbook on clinical trials methodology, written by recognized leaders who have long and extensive experience in all areas of clinical trials. The three authors of the first four editions have been joined by two others who add great expertise. A chapter on regulatory issues has been included and the chapter on data monitoring has been split into two and expanded. Many contemporary clinical trial examples have been added. There is much new mate...

The clinical trial is “the most definitive tool for evaluation of the applicability of clinical research.” It represents “a key research activity with the potential to improve the quality of health care and control costs through careful comparison of alternative treatments” [1]. It has been called on many occasions, “the gold st- dard” against which all other clinical research is measured. Although many clinical trials are of high quality, a careful reader of the medical literature will no...

This is the fifth edition of a very successful textbook on clinical trials methodology, written by recognized leaders who have long and extensive experience in all areas of clinical trials. The three authors of the first four editions have been joined by two others who add great expertise.This book is intended for the clinical researcher who is interested in designing a clinical trial and developing a protocol. It is also of value to researchers and practitioners who must criticall...

Vidám és tartalmas versekkel kísért fotóalbum készült a Debreceni Nagyerdő élővilágáról. Haszonnal forgathatják kicsik és azok a szülők, nagyszülők, akik szeretnének felkészülni a világot felfedező gyermekeik, unokáik „Mi ez?” kérdéseire.A kötet első felében a 2016-ban kiírt vers- és prózaíró pályázatunk díjazott munkái kaptak helyet. Itt gyerekek mondják el rövidebb írásaikban, nekik mit jelent, mit adott a Nagyerdő.

This is a comprehensive exposition of topics covered by the American Mathematical Society's classification "Global Analysis, dealing with modern developments in calculus expressed using abstract terminology. It will be invaluable for graduate students and researchers embarking on advanced studies in mathematics and mathematical physics.This book provides a comprehensive coverage of modern global analysis and geometrical mathematical physics, dealing with topics such as; structures on manif...

This text provides a solid understanding of the various statistical topics relevant to the design, monitoring, and analysis of a clinical trial. It covers basic experimental design, sample size, randomization procedures, interim and survival analyses, quality of life assessment, and longitudinal methods. The book describes all phases of a clinical trial and explores the advantages of and objections to the intent-to-treat principle as well as its implementation. With exercises at the end of...