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  • Monoamine Oxidase

    Methods and Protocols

    Edición de Claudia Binda ...
    Series series Springer Protocols
    This detailed book examines the main methods to study mammalian monoamine oxidases (MAOs), ranging from cell biology to computational chemistry. Beginning with techniques on how to obtain pure samples of MAO A and MAO B, the volume continues by covering assays and techniques used to measure MAO enzymatic activity and perform inhibition studies, methods to address cellular localization and function ... Leer más

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  • Aggregation of Therapeutic Proteins

    Edición de Wei Wang, Christopher J. Roberts ...
    This book gives pharmaceutical scientists an up-to-date resource on protein aggregation and its consequences, and available methods to control or slow down the aggregation process. While significant progress has been made in the past decade, the current understanding of protein aggregation and its consequences is still immature. Prevention or even moderate inhibition of protein aggregation has ... Leer más

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  • Chemical Genomics

    Edición de Haian Fu, PhD ...
    Advances in chemistry, biology and genomics coupled with laboratory automation and computational technologies have led to the rapid emergence of the multidisciplinary field of chemical genomics. This edited text, with contributions from experts in the field, discusses the new techniques and applications that help further the study of chemical genomics. The beginning chapters provide an overview of ... Leer más

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  • Molecular Analysis and Genome Discovery

    Edición de Ralph Rapley, Stuart Harbron ...
    Molecular Analysis and Genome Discovery, Second Edition is a completely revised and updated new edition of this successful book. The text provides a comprehensive overview of recent developments in the fast moving field of molecular based diagnostics of disease markers. Key concepts and applications are provided alongside practical information on current techniques currently being researched and ... Leer más

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  • The Biophysics of Cell Membranes

    Biological Consequences

    Series Libro 19 - Springer Series in Biophysics
    This volume focuses on the modulation of biological membranes by specific biophysical properties. The readers are introduced to emerging biophysical approaches that mimick specific states (like membrane lipid asymmetry, membrane curvature, lipid flip-flop, lipid phase separation) that are relevant to the functioning of biological membranes. The first chapter describes innovative methods to mimic ... Leer más

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  • Field-Flow Fractionation in Biopolymer Analysis

    Series series Chemistry and Material Science (R0)
    This is a timely collection of important biomedical applications for a set of separation/characterization techniques that are rapidly gaining popularity due to their wide dynamic range, high resolution, and ability to function in most commonly used solvent systems. Importantly, the field-flow fractionation (FFF) technique has recently emerged as a prominent complement to size exclusion ... Leer más

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  • Analytical Characterization of Biotherapeutics

    Edición de Jennie R. Lill, Wendy Sandoval ...
    The definitive guide to the myriad analytical techniques available to scientists involved in biotherapeutics researchAnalytical Characterization of Biotherapeutics covers all current and emerging analytical tools and techniques used for the characterization of therapeutic proteins and antigen reagents. From basic recombinant antigen and antibody characterization, to complex analyses for ... Leer más

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  • Protein and Peptide Mass Spectrometry in Drug Discovery

    The book that highlights mass spectrometry and its application in characterizing proteins and peptides in drug discoveryAn instrumental analytical method for quantifying the mass and characterization of various samples from small molecules to large proteins, mass spectrometry (MS) has become one of the most widely used techniques for studying proteins and peptides over the last decade. Bringing ... Leer más

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  • Peptide Therapeutics

    Fundamentals of Design, Development, and Delivery

    Edición de Seetharama D. Jois ...
    Series series Biomedical and Life Sciences (R0)
    This book explains how peptide-based drug design works, what steps are needed to develop a peptide-based therapeutic, and challenges in synthesis as well as regulatory issues. It covers the design concept of peptide therapeutics from fundamental principles using structural biology and computational approaches. The chapters are arranged in a linear fashion. A fresh graduate or a scientist who works ... Leer más

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  • HDAC/HAT Function Assessment and Inhibitor Development

    Methods and Protocols

    Edición de Oliver H. Krämer ...
    Series series Springer Protocols
    This fully updated edition provides a series of methods for how best to assess functions of histone deacetylases and acetyltransferases. The disease-relevance of dysregulated protein deacetylation by overexpressed or aberrantly activated histone deacetylases has spurred an intense search for novel and improved inhibitors of these enzymes, as reflected in this collection. Expert contributors ... Leer más

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  • Endocannabinoid Signaling

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    Edición de Mauro Maccarrone ...
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    This second edition provides new and updated chapters detailing all major elements of the ECB system. Chapters guide readers through identification of drug targets, electrophysiology, computational chemistry, and machine learning. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and ... Leer más

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  • The Ubiquitin Code

    Edición de Manuel S Rodriguez, Rosa Barrio ...
    Series series Springer Protocols
    This volume details novel and popular approaches to decipher the Ubiquitin Code. Chapters guide readers through ubiquitin chain complexity, methods to generate non-hydrolysable ubiquitin-NEDD8, a fully synthetic method for the linear synthesis of fluorescently labelled rhodamine LC3A and LC3B, a HECT ligase-mediated ubiquitylation in vitro, a RNAi-based screening to identify DUBs, a Yuh1 activity ... Leer más

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