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Springer Protocols Serie de eBooks

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  • Cell-Wide Identification of Metabolite-Protein Interactions

    Edición de Aleksandra Skirycz, Marcin Luzarowski, Jennifer C. Ewald ...
    Series series Springer Protocols
    This thorough volume explores protocols of proteome- and metabolome-wide strategies for the identification of protein-small molecule complexes in different organisms, in order to shed light on these important regulatory interactions. Experimental and computational strategies to characterize protein-metabolite interactions are discussed, and recent advances in enabling technologies are featured as ... Leer más

    $112,372 CLP

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  • Chemical Genomics

    Edición de Haian Fu, PhD ...
    Advances in chemistry, biology and genomics coupled with laboratory automation and computational technologies have led to the rapid emergence of the multidisciplinary field of chemical genomics. This edited text, with contributions from experts in the field, discusses the new techniques and applications that help further the study of chemical genomics. The beginning chapters provide an overview of ... Leer más

    $122,162 CLP

  • Peptide Therapeutics

    Strategy and Tactics for Chemistry, Manufacturing, and Controls

    Edición de Ved Srivastava ...
    Series Libro 72 - Drug Discovery Series
    Peptide therapy has become a key strategy in innovative drug development, however, one of the potential barriers for the development of novel peptide drugs in the clinic is their deficiencies in clearly defined chemistry, manufacturing and controls (CMC) strategy from clinical development to commercialization. CMC can often become a rate-limiting step due to lack of knowledge and lack of a formal ... Leer más

    $241,151 CLP

  • Drug Design

    Structure- and Ligand-Based Approaches

    Edición de Kenneth M. Merz, Jr, PhD, Dagmar Ringe, PhD, Charles H. Reynolds, PhD ...
    Structure-based (SBDD) and ligand-based (LBDD) drug design are extremely important and active areas of research in both the academic and commercial realms. This book provides a complete snapshot of the field of computer-aided drug design and associated experimental approaches. Topics covered include X-ray crystallography, NMR, fragment-based drug design, free energy methods, docking and scoring, ... Leer más

    $136,224 CLP

  • Scaffold Hopping in Medicinal Chemistry

    de Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ...
    Series Libro 58 - Methods & Principles in Medicinal Chemistry
    This first systematic treatment of the concept and practice of scaffold hopping shows the tricks of the trade and provides invaluable guidance for the reader's own projects.The first section serves as an introduction to the topic by describing the concept of scaffolds, their discovery, diversity and representation, and their importance for finding new chemical entities. The following part ... Leer más

    $107,997 CLP

  • Fragment-based Drug Discovery

    Lessons and Outlook

    de Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ...
    Series series Methods & Principles in Medicinal Chemistry
    From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed ... Leer más

    $145,848 CLP

  • Protein and Peptide Mass Spectrometry in Drug Discovery

    Edición de Michael L. Gross, Guodong Chen, Birendra Pramanik ...
    The book that highlights mass spectrometry and its application in characterizing proteins and peptides in drug discoveryAn instrumental analytical method for quantifying the mass and characterization of various samples from small molecules to large proteins, mass spectrometry (MS) has become one of the most widely used techniques for studying proteins and peptides over the last decade. Bringing ... Leer más

    $138,865 CLP

  • Protein Engineering Techniques

    Gateways to Synthetic Protein Universe

    de Krishna Mohan Poluri, Khushboo Gulati ...
    Series series Engineering (R0)
    This brief provides a broad overview of protein-engineering research, offering a glimpse of the most common experimental methods. It also presents various computational programs with applications that are widely used in directed evolution, computational and de novo protein design. Further, it sheds light on the advantages and pitfalls of existing methodologies and future perspectives of protein ... Leer más

    $56,180 CLP

  • Biomolecular Forms And Functions: A Celebration Of 50 Years Of The Ramachandran Map

    de Manju Bansal, Narayanaswamy Srinivasan ...
    Understanding the functions and properties of molecules in living systems requires a detailed knowledge of their three-dimensional structures and the conformational variability that allows them to adopt multiple functional forms. Interpreting biological systems in the language of three-dimensional structures is of fundamental importance and innumerable research groups around the world are working ... Leer más

    $59,806 CLP

  • Disruption of Protein-Protein Interfaces

    In Search of New Inhibitors

    Edición de Stefano Mangani ...
    Series series Chemistry and Material Science (R0)
    "Disruption of Protein-Protein Interfaces" reviews the latest developments and future perspectives in drug discovery at protein-protein interfaces. The authors detail experimental and computational tools to tackle the subject and highlight the contribution of the Italian research community to the field. Evidence shows that blocking or modulating protein-protein interactions might lead to the ... Leer más

    $101,133 CLP

  • Analytical Characterization of Biotherapeutics

    Edición de Jennie R. Lill, Wendy Sandoval ...
    The definitive guide to the myriad analytical techniques available to scientists involved in biotherapeutics researchAnalytical Characterization of Biotherapeutics covers all current and emerging analytical tools and techniques used for the characterization of therapeutic proteins and antigen reagents. From basic recombinant antigen and antibody characterization, to complex analyses for ... Leer más

    $165,873 CLP

  • Molecular Analysis and Genome Discovery

    Edición de Ralph Rapley, Stuart Harbron ...
    Molecular Analysis and Genome Discovery, Second Edition is a completely revised and updated new edition of this successful book. The text provides a comprehensive overview of recent developments in the fast moving field of molecular based diagnostics of disease markers. Key concepts and applications are provided alongside practical information on current techniques currently being researched and ... Leer más

    $119,572 CLP