From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed.The first part discusses basic considerations of when to use fragment-based methods, how...

What’s Old Is New – and Surprisingly Strong! The world’s oldest opening variation, 3...Qd8 in the Scandinavian Defense, has resurfaced in the last decade to give players at all levels a winning edge. Whether you prefer a sharp tactical game or slower positional maneuvering, the 3...Qd8 Scandinavian provides a genuine alternative for club players and grandmasters seeking to play for a win from the outset. Elite players such as Michael Adams, Josif Dorfman, Kiril Georgiev and Julian Ho...

Win at Chess is the ultimate beginner's guide to this complex tactical game. You will quickly get to grips with the pieces, basic moves and elementary tactics - to help you develop your strategy and win. You will build your skill and learn how to exploit your opponent's strengths and weaknesses to ultimately force checkmate. The book is packed with new interactive features which include tips and commentaries on historic games and exercises for the reader.It won't overburden you wit...

Master the game of Japanese Chess-or shogi with this easy to follow shogi guide.The game of shogi is a chess-like game of strategy long played in Japan. This book is the ultimate strategy guide on shogi for beginners and experienced players alike. The step-by-step instructions an easy to follow diagrams lead the reader through the strategies and intricacies of one of Japan's most popular war games.The book includes explanations of:...

This book serves as a reference text for regulatory, industry and academic statisticians and also a handy manual for entry level Statisticians. Additionally it aims to stimulate academic interest in the field of Nonclinical Statistics and promote this as an important discipline in its own right. This text brings together for the first time in a single volume a comprehensive survey of methods important to the nonclinical science areas within the pharmaceutical and biotechnology industries. ...

Nowadays, chessplayers spend almost all their free time preparing openings, and rarely spend the time necessary to perfect the vitally important technique of calculating. Regular training in solving and playing out endgames studies is a good recipe for eliminating that shortcoming. This training is directed at developing resourcefulness, fantasy (in chess, these qualities are called "combinative acuityâ€), and the readiness to sacrifice material, in pursuit of the goal - winning! How...

The ACMT National Case Conference (NCC) is a monthly discussion of novel or interesting cases in medical toxicology. Participation is through online webinar, and the conferences are recorded to allow for review at any time. The cases in this book are taken from recordings of NCC with edits and revisions by contributors and editors to demonstrate educational points. The majority of the case information is from the original recording and represents actual patient presentations. However, some...

Nanobiomaterials in Cancer Therapy presents the major applications of nanobiomaterials in oncology, offering an up-to-date overview of the latest research in this field. Utilizing nanobiomaterials, novel therapeutic approaches enable significant improvements in drug-loading capacity, formulation stability and drug efficiency. In this book, leading researchers from around the world share their expertise and unique insights. The book covers the fabrication methods of platforms for multimodal...

This comprehensive text presents a rigorous framework from within which regulators can respond strategically to the claim by the pharmaceutical industry that lower drug prices today lead to a loss for the population’s future health due to less innovation. It starts with a critical review of the empirical evidence of the return to consumers on their ongoing investment into high drug prices in order to increase future innovation. The implicit, critical and unrealistic assumption inherent in ...

Recent and rapid progress in the field of biotechnology has resulted in an increasing number of novel macromolecular drugs with great promise for further advanced research and clinical application. However, the delivery of these macromolecular drugs by routes other than the parenteral route is difficult. The pipeline of macromolecular drugs derived from biotechnology presents a challenging opportunity to develop practical dosage forms that could be dosed via the oral route. Given this, the...

Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation.The main part of the book describes examples of protein targets for which small molecule modulators have been developed, covering such diverse fields as cancer, autoimmune disorders and infectious diseases. Tailor-made for the practicing med...