The authoritative guide for Data Monitoring Committees—fully revised and updatedThe number of clinical trials sponsored by government agencies and pharmaceutical companies has grown in recent years, prompting an increased need for interim monitoring of data on safety and efficacy. Data Monitoring Committees (DMCs) are an essential component of many clinical trials, safeguarding trial participants and protecting the credibility and validity of the study. Data Mo...

A compelling, intimate look at the founders—George Washington, Ben Franklin, John Adams, Thomas Jefferson, Alexander Hamilton, and James Madison—and the women who played essential roles in their livesWith his usual storytelling flair and unparalleled research, Tom Fleming examines the women who were at the center of the lives of the founding fathers. From hot-tempered Mary Ball Washington to promiscuous Rachel Lavien Hamilton, the founding fathers' mothers powerfully shaped their s...

New York Times bestselling historian Thomas Fleming creates a dramatic, moving depiction of the Siege of Yorktown - the days in October 1781 that ended the American Revolution and changed the world. Along with French General Jean-Baptiste Rochambeau, George Washington made an astonishing march through New Jersey and trapped British General Charles Cornwallis and his forces in Yorktown, Virginia, where they unleashed a tremendous artillery assault, with the support of the French navy. But v...

Liberty! brings to life one of the most important and compelling stories in America's history: the struggle for independence and the birth of the nation. New York Times bestselling historian Thomas Fleming's gripping narrative captures the high drama of the revolutionary war years and the unyielding courage and political genius of the men and women who imagined a new set of political possibilities for humankind - laying the foundation for the identity and character of the American people i...

In this New York Times bestseller, historian Thomas Fleming examines all the dimensions of the memorable year of 1776 - particularly the common, fallible humanity of the men and women of the American Revolution. The year 1776 ended with both the Americans and the British stripped of their illusions. Each side had been forced to abandon the myth of invincibility and confront the realities of human nature on and off the battlefield. For the Americans, it had been a shock to discover that it ...

Even his abolitionist allies thought his attack on Harpers Ferry insane, but, as this short-form book by New York Times bestselling historian Thomas Fleming points out, John Brown sensed that his trial and death would ignite the nation's conscience.

Defeated by Americans at Saratoga, British General John Burgoyne's troops faced nearly five years of enforced exile in a hostile countryside. Here, in this short-form book by New York Times bestselling author Thomas Fleming, is the dramatic story of Burgoyne and his wandering soldiers.

Seventy-year-old Benjamin Franklin charmed Paris and pulled off a diplomatic miracle that led to the British defeat in the American Revolution. Here, in this essay from New York Times bestselling author Thomas Fleming is the little-told story.

Thomas Fleming is best known as a historian of the American Revolution and a biographer of America's founding fathers. But, as the following collection shows, this award-winning writer, whose career spanned more than fifty years, also explored with equal passion and curiosity the history of other, later eras. Spanning the generations from the beginnings of the United States to modern times, these chronicles explore events and decisions that continue to have an impact the nation to this day...

Fifty-five men from 12 virtually autonomous states came to Philadelphia in 1787 in a brave - some thought foolhardy - attempt to replace a loose and fragile confederation with a strong national government. They were politicians, judges, governors, and Revolutionary War veterans. Thomas Jefferson called them "demigods." For a long, hot summer they debated, argued, and compromised. In the end, they carved out a bold new document designed to "secure the blessings of liberty" for Americans. Th...

When Sir William Howe, commander-in-chief of the British Army in America, and his brother, Admiral Richard Howe, cornered General George Washington’s army on Manhattan Island, they politely asked the Americans if they wanted to surrender. The British gave the Americans two weeks to think it over, time Washington used to strengthen his troops for another round of fighting. Here, in this short-form book by New York Times bestselling historian Thomas Fleming, is the surprising story of how Wi...

New York Times bestselling historian Thomas Fleming brings his extraordinary biographical talents to bear upon Benjamin Franklin, perhaps the least understood of America's revolutionary giants. For this reappraisal, Fleming concentrates on the mature Franklin, the man who lived nearly thirty years beyond the point where he ended his famous Autobiography. The poor boy, the miserly young printer, has become a decidedly more complex and cultured man. In scene after vivid scene, Fleming shows ...