The book summarizes the main results of the the project ENABLE-S3 covering the following aspects: validation and verification technology bricks (collection and selection of test scenarios, test executions envionments incl. respective models, assessment of test results), evaluation of technology bricks in selected use cases and standardization and related initiatives. ENABLE-S3 is an industry-driven EU-project and aspires to substitute todays' cost-intensive verification and validation effo...