Since the epochal discovery of the radical and highly toxic gas nitric oxide (NO) as a signaling molecule, two other no less toxic gases – carbon monoxide (CO) and hydrogen sulfide (H2S) – have been found to also be involved in a plethora of physiological and pathophysiological functions. The gases termed gasotransmitters play an increasingly important role in understanding how signalling into and between cells is modulated and fine-tuned. The advent of gasotransmitters has profou...

Originally published in 1973. Aristotle’s early works probably belong to the formative era of his philosophic thought and as such contribute vitally to the understanding and evaluation of the development of his philosophy. This book shows that the philosophy propagated in these lost works indicates an undeniable Platonism, and thus seems to conflict with the basic doctrines in the traditional treatises collected in the Corpus Aristotelicum. Was the author of the lost early works a...

Originally published in 1973. The predominantly historical approach in this book heralds a belief that a better understanding of Aristotle the man, and the salient events of his life, leads to a greater insight into his work as a philosopher. This, the first of two volumes, presents interpretations of Aristotle’s life, widely interesting to any Aristotle scholars.

The purpose of this book, first published in 1957, is to make a critical analysis of the controversial Socratic problem. The Socratic issue owes its paramount difficulty not only to the status of available source materials, but also to the diversity of opinion as to the proper use of these materials. This volume offers a new approach to the problem, and a starting point to further investigations.

This first volume in a projected series contains the proceedings of the first of the Keio University International Symposia for Life Sciences and Medicine under the sponsorship of the Keio University Medical Science Fund. As stated in the address by the President of Keio University at the opening of the 1996 symposium, the fund of Dr. Mitsunada Sakaguchi. The Keio was established by the generous donation University International Symposia for Life Sciences and Medicine constitute one of the...

A Chinese classic of the "inner alchemy" of Taoism, this book was first translated by Richard Wilhelm (also translator, in the 1920s, of the Chinese philosophical classic the I Ching). Wilhelm, was German, and his translations from Chinese to German were later translated to English by Cary F. Baynes. According to Wilhelm, LuDongbin was the main originator of the material presented in the book suggests that the material is from Quanzhen School founder Wang Chongyang, a student of Lu Dongbin...

This book is a compendium of proceedings from the Symposium on Growth Hormone II: Basic and Clinical Aspects. The intent of the sym posium was to review current aspects of the rapidly expanding science of growth hormone (GH) neuroendocrinology, especially those develop ments that occurred since our last meeting in 1985. The meeting was timely since there have been many new and exciting developments in basic research on the GH axis, and several new clinical applications for GH other than gr...

The Praise of Folly is Erasmus's dazzling satirical oration in which Folly, personified as a learned yet irreverent speaker, praises herself while exposing the vanities of theologians, courtiers, monks, scholars, and rulers. Written in elegant Latin and steeped in classical rhetoric, Lucianic wit, and biblical moral critique, the work belongs to the humanist culture of the Northern Renaissance, where laughter becomes an instrument of reform. Its irony is playful but exacting, revealing how...

This book presents an overview of the entire field of cadherin research and provides the current basic concept of cadherins. Cadherins have been widely accepted as key regulators of animal development and physiological functions, and it also has become clear that they play essential roles in various human diseases. With contributions by leading scientists, the book covers various aspects of the cadherin superfamily including the history of cadherin research, basic properties of classical c...

1 Purpose and Plan of This Review This review is focused on the topography and connections of some of the neuron populations that determine the manual dexterity of the macaque monkey. The populations selected for examination are the following: 1. The corticospinal neuron populations 2. The thalamocortical and corticothalamic neuron populations associated with the sensorimotor cortex 3. The ipsilateral cortical connections of the sensorimotor cortex These neuron populations have been ...

Twenty-five years ago, Earl R. Stadtman, PhD discovered that specific enzymes regulating metabolism can be inactivated by oxidation [1]. He later showed that age-related oxidative modification contributes, at least in part, to age-related loss of function of the enzymes [2, 3]. Dr. Stadtman broke the ground for a new field of study to discover how oxidative stress contributes in significant ways to age-related cellular dysfunction and protein accumulation and that oxidation in the aging br...

The Epistulae morales ad Lucilium (English: Moral Epistles to Lucilius) is a collection of 124 letters which were written by Seneca the Younger at the end of his life. They are addressed to Lucilius, the then procurator of Sicily, although he is known only through Seneca's writings. In these letters, Seneca gives Lucilius tips on how to become a more devoted Stoic. Lucilius was, at that time, the Governor of Sicily, although he is known only through Seneca's writings. Selected from the Epi...