Homeostatic Control of Brain Function offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss of homeostasis becomes expressed as a diverse array of neurological disorders. Each disorder has multiple comorbidities - with some crossing over several conditions - and often disease-specific treatments rem...

Homeostasis of key metabolites and metabolic health affects all bodily systems. Not surprisingly, altered metabolic function is associated with a wide spectrum of dysfunctions in the central nervous system – including developmental disorders, acute nervous system injury, and neurodegenerative disorders. Accordingly, metabolism-based therapies offer significant promise as new category of treatment options designed to limit, delay or reverse the disease process by reconstructing homeostatic ...

This book highlights the state of the field in the new, provocative line of research into the cognition and behavior of the domestic dog. Eleven chapters from leading researchers describe innovative methods from comparative psychology, ethology and behavioral biology, which are combined to create a more comprehensive picture of the behavior of Canis familiaris than ever before. Each of the book’s three parts highlights one of the perspectives relevant to providing a full understanding of t...

An extraordinary memoir about the cutting-edge brain therapy that dramatically changed the life and mind of John Elder Robison, the New York Times bestselling author of Look Me in the EyeNAMED ONE OF THE BEST BOOKS OF THE YEAR BY THE WASHINGTON POSTImagine spending the first forty years of your life in darkness, blind to the emotions and social signals of other people. Then imagine that someone suddenly switch...

Neurosciences – a comprehensive approachThis textbook covers neuroscience from cellular and molecular mechanisms to behavior and cognitive processing. We also address evolution of the nervous system, computational neuroscience, the history of neuroscience as a discipline and neurophilosophy – to name but a few. The book provides the newest state-of-the-art knowledge about neuroscience from across the animal kingdom, with particular emphasis on model specie...

The perception-action cycle is the circular flow of information that takes place between the organism and its environment in the course of a sensory-guided sequence of behaviour towards a goal. Each action causes changes in the environment that are analyzed bottom-up through the perceptual hierarchy and lead to the processing of further action, top-down through the executive hierarchy, toward motor effectors. These actions cause new changes that are analyzed and lead to new action, and so ...

Twenty-five years ago, Earl R. Stadtman, PhD discovered that specific enzymes regulating metabolism can be inactivated by oxidation [1]. He later showed that age-related oxidative modification contributes, at least in part, to age-related loss of function of the enzymes [2, 3]. Dr. Stadtman broke the ground for a new field of study to discover how oxidative stress contributes in significant ways to age-related cellular dysfunction and protein accumulation and that oxidation in the aging br...

Positive, practical and realistic, this book offers a wealth of information on women, dating and relationships for men with Asperger Syndrome (AS).Many AS men are totally confused and bewildered by women and relationships and find it hard to know what to do, what to say and how to get it right. For these men, understanding the emotional side to relationships and women's needs can be a complete mystery and they often get it disastrously wrong. This practical handbook provides the an...

A brain-computer interface (BCI) establishes a direct output channel between the human brain and external devices. BCIs infer user intent via direct measures of brain activity and thus enable communication and control without movement. This book, authored by experts in the field, provides an accessible introduction to the neurophysiological and signal-processing background required for BCI, presents state-of-the-art non-invasive and invasive approaches, gives an overview of current hardwar...

This book is a celebration of all the wonderful and unexpected gifts that having a daughter on the autism spectrum can bring to a family. Each chapter offers encouragement and guidance on issues such as school, friendships, meltdowns, special gifts, family relationships, therapies and interventions. Having daughters on the spectrum presents unique and rewarding challenges and this book is packed with friendly advice and real life examples from a mother who has experienced it all first hand...

This issue of Current Topics in Behavioral Neuroscience focuses on the neuropeptide orexin (hypocretin) and brings together scientists from around the world who will provide a timely discussion of how this peptide regulates behavior. This is a fast-moving field, and with the incorporation of novel technologies, new breakthroughs are likely to continue. For example, the use of optogenetic approaches has enabled the identification of the role of orexin-containing neurons in arousal ...

The Springer Handbook of Auditory Research presents a series of com prehensive and synthetic reviews of the fundamental topics in modern auditory research. The volumes are aimed at all individuals with interests in hearing research including advanced graduate students, post-doctoral researchers, and clinical investigators. The volumes are intended to intro duce new investigators to important aspects of hearing science and to help established investigators to better understand the fundament...