Clinical trials sit at the center of how new medical therapies move from early scientific promise to safe, effective, and available treatment. Every stage of that journey — designing a protocol, finding the right participants, monitoring their safety, analyzing the resulting evidence, and ultimately gaining regulatory approval — has traditionally depended on expert judgment applied to data that arrives slowly and in fragments. Artificial intelligence is changing what's possible at each of ...

The apocalypse will come in A is for Apocalypse, but in a many different forms. Within these covers the apocalypse comes with fire, with a sigh, with tears, in technological code, with alien intervention. It comes with survival in a nightmare landscape, it demands human sacrifice, it stalks through the pages with bloodlust. It freezes, it explodes, it howls.In stories as varied as the trials humanity can endure, this anthology brings together an alphabet of possible world ...

My Secret Life brought us the story of Walter and his unerring pursuit of sexual pleasures unabashed by the conformity about him. In 'Eveline' however, we have a rare example of a woman's perspective on sexual liberation, as our heroine embarks on a grand voyage of the male and female physique, savouring all from stable boy to sailor to lord and lady.Altogether headstrong and knowledgeable in the deeds and devices of libertine pleasures, Eveline lives to experience the sup...

Disjointed (688 pages in print) is for patients with hEDS/HSD and the physicians who treat them. hEDS/HSD is an underrecognized, complex, multisystemic disorder, with the silos of healthcare’s specialties often working against effective and efficient treatment. With 21 specialist & 6 resource chapters, Disjointed brings together physician, patient, and parent perspectives to support the goal of earlier and more complete intervention. With specialist chapters by: Paldeep Atwal, M.D., Richar...

When his drunken and impoverished brother dies, Lord Roxboro is none too pleased to discover he is to act as ward to two nieces for surely they will be the dirty brats he remembers and will cost him dearly of his dwindling fortunes. However, as they depart the stagecoach at the door of his mansion what he sees are anything but childlike or urchin, his eyes in fact falling upon two young woman of stunning beauty and grace.Roxboro house is a den of the most libidinous and scandalous ...

This deliciously decadent once-banned classic of vintage erotica, written anonymously in 1890, tells the wild and sordid story of a head-strong and fiercely confident young woman as she navigates the kinky and the morally loose corners, boudoirs, and parties of Victorian high-society.In the great tradition of 'Fanny Hill', Arabella, in her own words describes her remarkable life seeking all manner of erotic diversions.Her journey begins at a very exclusive party of the era;...

Written anonymously in 1908 this four volume work must be one of the most uncompromising pieces to emerge from the Victorian erotic underground. If the writer was attempting to emulate De Sade, then the author has succeeded.'The Way of a Man with a Maid', as told by its main protagonist, Jack, recounts in graphic detail the 'training' and eventual sexual liberation of a number of young women who had previously spurned his advances. In the 'snuggery', Jack's well equipped room of de...

The young and handsome new Abbot of Motte-sur-Vy, Father Pineraide, is not as pure as his parishioners would believe. Leaving many a girls swooning at first meeting, our salacious man of the cloth wastes no time pursuing the lithe young women he first meets. Confessing her sins to him in his own house; that she has had impure thoughts of him while satisfying herself, Father Pinerade suggests blessing her with his holy rod to absolve her fully and completely, within and without.What...

Lady Harpur returns to narrate this grand homage to all things licentious. Together with Lord Ferrars, she and her husband plays host to a group that have no physical or moral boundaries at all. Partaking in all deeds and devices front and back, ménage, lesbian tribadism, and gamahuching a plenty, it is not long before their newest recruit and eager young disciple Clara loses herself in the wildest and most unrestrained of sexual abandons.Pseudonymously written in 1885 and publishe...

When Caroline enters Harry's world, he is not quite so prepared for her forwardness, vigour, and general moral and sexual abandon. Seducing Harry's sister Adelaide, a young woman ignored by her husband in all things intimate, Caroline penetrates deep into the hearts and souls of siblings yearning for the kind of liberation she all too freely exhibits.On becoming Harry's wife Caroline, keen to share in her free love philosophy and finding Harry none too resistant, opens up their hou...

When Adelina is caught in the most compromising of positions, she is soon sent to a convent school for wayward adolescents in far off France.The first part of this gem describes our female protagonist’s first tastes of lust as she embarks on a torrid and forbidden love affair with her tutor. Their gradual draw to one another is wonderfully erotic, each attempting to hold back but unable to do so. The old monk, eager not to spoil Adelina's virginity, introduces her to all those forb...

In order to escape the Republican purges of revolutionary France, Augustus and his mother must take refuge in his Aunt's nunnery, the Convent of St. Claire. Dressed to deceive and going by the name of 'Augustine' he soon bears witness to the most lascivious acts of chastisement at the hands of one lusty Father Eustace upon one young, lithe, and eager Sister Emilie.What follows is a thoroughly mischievous frolic from one nun to another, all willing to be so educated in the sins of t...