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Targeting Enzymes for Pharmaceutical Development

Methods and Protocols

Edición de Nikolaos Labrou ...

Series series Springer Protocols
This second edition volume expands on the previous edition with a discussion of the latest experimental and computational strategies used in the study, characterization, and targeting of enzymes with therapeutic potential. The chapters in the book are organized into two parts: Part One presents detailed, reproducible protocols for enzyme characterization, inhibitor screening, and biochemical ... Leer más

$179,802 CLP

This second edition volume expands on the previous edition with a discussion of the latest experimental and computational strategies used in the study, characterization, and targeting of enzymes with therapeutic potential. The chapters in the book are organized into two parts: Part One presents detailed, reproducible protocols for enzyme characterization, inhibitor screening, and biochemical
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Applied Computer-Aided Drug Design: Models and Methods

de Igor José dos Santos Nascimento ...

Designing and developing new drugs is an expensive and time-consuming process, and there is a need to discover new tools or approaches that can optimize this process. Applied Computer-Aided Drug Design: Models and Methods compiles information about the main advances in computational tools for discovering new drugs in a simple and accessible language for academic students to early career ... Leer más

$73,953 CLP

Designing and developing new drugs is an expensive and time-consuming process, and there is a need to discover new tools or approaches that can optimize this process. Applied Computer-Aided Drug Design: Models and Methods compiles information about the main advances in computational tools for discovering new drugs in a simple and accessible language for academic students to early career
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Mass Spectrometry-Based Proteomics

Edición de Kris Gevaert ...

Series series Springer Protocols
This detailed volume explores contemporary techniques in mass spectrometry-based proteomics. After covering overall proteome coverage and the cellular surfaceome, the book delves into proximity-induced biotinylation, abduction of protein complexes in viral-like particles, and thermal proteome profiling, as well as protocols for identifying protein N-terminal acetylation, protein processing by ... Leer más

$189,049 CLP

This detailed volume explores contemporary techniques in mass spectrometry-based proteomics. After covering overall proteome coverage and the cellular surfaceome, the book delves into proximity-induced biotinylation, abduction of protein complexes in viral-like particles, and thermal proteome profiling, as well as protocols for identifying protein N-terminal acetylation, protein processing by
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IMMUNO-model in Cancer

Methods and Protocols

Edición de Sweta Rani, Lukasz Skalniak ...

Series series Springer Protocols
This open access volume describes the computational and experimental models that help researchers understand the responses of the immune system in cancer and test experimental immune-oncology approaches. The chapters in this book cover methods such as profile polarization in macrophages using ELISA; immune checkpoint inhibitors; interactions of PD-1/PD-L1 and T cells; immunocompetent preclinical ... Leer más

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This open access volume describes the computational and experimental models that help researchers understand the responses of the immune system in cancer and test experimental immune-oncology approaches. The chapters in this book cover methods such as profile polarization in macrophages using ELISA; immune checkpoint inhibitors; interactions of PD-1/PD-L1 and T cells; immunocompetent preclinical
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Clinical Metabolomics

Methods and Protocols

Edición de Martin Giera, Elena Sánchez-López ...

Series series Springer Protocols
This second edition volume presents new and updated protocols on comprehensive compendium of clinical metabolomics protocols covering LC-MS, GC-MS, CE-MS, and NMR-based clinical metabolomics as well as bioinformatics and study design considerations. Chapters explore the core of several promising initiatives evolving around personalized health care and precision medicine. Written for the highly ... Leer más

$202,277 CLP

This second edition volume presents new and updated protocols on comprehensive compendium of clinical metabolomics protocols covering LC-MS, GC-MS, CE-MS, and NMR-based clinical metabolomics as well as bioinformatics and study design considerations. Chapters explore the core of several promising initiatives evolving around personalized health care and precision medicine. Written for the highly
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Modern Proteomics – Sample Preparation, Analysis and Practical Applications

Edición de Hamid Mirzaei, Martin Carrasco ...

Series series Biomedical and Life Sciences (R0)
This volume serves as a proteomics reference manual, describing experimental design and execution. The book also shows a large number of examples as to what can be achieved using proteomics techniques. As a relatively young area of scientific research, the breadth and depth of the current state of the art in proteomics might not be obvious to all potential users. There are various books and review ... Leer más

$168,562 CLP

This volume serves as a proteomics reference manual, describing experimental design and execution. The book also shows a large number of examples as to what can be achieved using proteomics techniques. As a relatively young area of scientific research, the breadth and depth of the current state of the art in proteomics might not be obvious to all potential users. There are various books and review
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Mass Spectrometry Based Single Cell Proteomics

Edición de Akos Vegvari, Jaakko Teppo, Roman A. Zubarev ...

Series series Springer Protocols
This volume explores the latest advancements made in the field of mass spectrometry (MS) based single cell proteomics. The chapters in this book focus on technologies, methods, and biological applications and together cover the entire single cell proteomics analysis workflow, from sample collection and preparation through liquid chromatographic separation and mass spectrometric data acquisition to ... Leer más

$146,087 CLP

This volume explores the latest advancements made in the field of mass spectrometry (MS) based single cell proteomics. The chapters in this book focus on technologies, methods, and biological applications and together cover the entire single cell proteomics analysis workflow, from sample collection and preparation through liquid chromatographic separation and mass spectrometric data acquisition to
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SH2 Domains

Functional Modules and Evolving Tools in Biology

Edición de Teresa Carlomagno, Maja Köhn ...

Series series Springer Protocols
This volume looks at the latest methods used to study and modulate the biological function and mechanisms of SH2 domains. The chapters in this book are organized into five parts. Part One presents methodology aimed at determining the structures and dynamics of SH2 domains and their complexes with phosphopeptides. Part Two discusses techniques to understand and predict interactions of SH2 domains ... Leer más

$189,049 CLP

This volume looks at the latest methods used to study and modulate the biological function and mechanisms of SH2 domains. The chapters in this book are organized into five parts. Part One presents methodology aimed at determining the structures and dynamics of SH2 domains and their complexes with phosphopeptides. Part Two discusses techniques to understand and predict interactions of SH2 domains
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Separation Techniques Applied to Omics Sciences

From Principles to Relevant Applications

Edición de Ana Valéria Colnaghi Simionato ...

Series series Biomedical and Life Sciences (R0)
This book covers liquid chromatography, gas chromatography and capillary electrophoresis, the three main separation techniques lately available, applied to key omic sciences, such as genomics, proteomics, metabolomics and foodomics. The fundamentals of each technique are not covered herein. Instead, the recent advances in such techniques are presented focusing on the application to omics analyses ... Leer más

$191,039 CLP

This book covers liquid chromatography, gas chromatography and capillary electrophoresis, the three main separation techniques lately available, applied to key omic sciences, such as genomics, proteomics, metabolomics and foodomics. The fundamentals of each technique are not covered herein. Instead, the recent advances in such techniques are presented focusing on the application to omics analyses
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Structural Genomics and Drug Discovery

Methods and Protocols

Edición de Wayne F. Anderson ...

Series series Springer Protocols
Structural Genomics and Drug Discovery: Methods and Protocols focuses on high throughput structure determination methods and how they can be applied to lay the groundwork for structure aided drug discovery. The methods and protocols that are described can be applied in any laboratory interested in using detailed structural information to advance the initial stages of drug discovery. Written in the ... Leer más

$112,372 CLP

Structural Genomics and Drug Discovery: Methods and Protocols focuses on high throughput structure determination methods and how they can be applied to lay the groundwork for structure aided drug discovery. The methods and protocols that are described can be applied in any laboratory interested in using detailed structural information to advance the initial stages of drug discovery. Written in the
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Target Identification and Validation in Drug Discovery

Methods and Protocols

Edición de Jürgen Moll, Sebastian Carotta ...

Series series Springer Protocols
This third edition book explores breakthrough techniques in the field of drug target identification and validation. With technologies and methodologies ranging from target identification to the analysis of clinical samples, as well as newer areas like artificial intelligence and machine learning applications, the book will aid decision-makers in drug development by offering a succinct overview of ... Leer más

$191,039 CLP

This third edition book explores breakthrough techniques in the field of drug target identification and validation. With technologies and methodologies ranging from target identification to the analysis of clinical samples, as well as newer areas like artificial intelligence and machine learning applications, the book will aid decision-makers in drug development by offering a succinct overview of
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Cell-Wide Identification of Metabolite-Protein Interactions

Edición de Aleksandra Skirycz, Marcin Luzarowski, Jennifer C. Ewald ...

Series series Springer Protocols
This thorough volume explores protocols of proteome- and metabolome-wide strategies for the identification of protein-small molecule complexes in different organisms, in order to shed light on these important regulatory interactions. Experimental and computational strategies to characterize protein-metabolite interactions are discussed, and recent advances in enabling technologies are featured as ... Leer más

$112,372 CLP

This thorough volume explores protocols of proteome- and metabolome-wide strategies for the identification of protein-small molecule complexes in different organisms, in order to shed light on these important regulatory interactions. Experimental and computational strategies to characterize protein-metabolite interactions are discussed, and recent advances in enabling technologies are featured as
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Targeting Enzymes for Pharmaceutical Development

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Applied Computer-Aided Drug Design: Models and Methods

Mass Spectrometry-Based Proteomics

IMMUNO-model in Cancer

Clinical Metabolomics

Modern Proteomics – Sample Preparation, Analysis and Practical Applications

Mass Spectrometry Based Single Cell Proteomics

SH2 Domains

Separation Techniques Applied to Omics Sciences

Structural Genomics and Drug Discovery

Target Identification and Validation in Drug Discovery

Cell-Wide Identification of Metabolite-Protein Interactions