Science projects at Hemlock require more than a fizzy volcano to impress the class, so naturally Kazu introduces them to Pandora, whose violent streak and impressive strength cause more destruction in his already chaotic school life. Braving runaway science experiments, howling apparitions and a deadly fashion show, Pandora learns that life at a devil high school is a day-to-day struggle for survival.

At Hemlock Heart Academy, science wiz Kazu Decker shows off his skills by creating a humanoid girl named Pandora. But in a world of monsters and mayhem, surviving high school is harder than getting good grades and lessons often turn violent at Hemlock. Fortunately for them, Pandora’s stoic nature and seemingly limitless strength, paired with Kazu’s luck, knowledge and friends, get them out of trouble almost as often as it gets them mixed up in it!

Kazu is having a hard time getting used to Pandora’s growing independence, but then an elite rival academy, Sacred Crown, challenges the ill-matched students of Hemlock Heart to a violent game of Eggscram. Pandora’s unlimited strength soon gets recognized by a society of sinister daemons beyond the schoolyard, and now it’s not just Kazu who wants Pandora’s attention! Is Pandora prepared to take the step from schoolyard skirmishes into the wrath of the daemon world?

Pandora’s run-in with Scarlet Crown agents Strazio and Pia exposes Kazu and their new friends to the dangerous daemon crime world that runs the town. Just as Kazu’s scientific prowess helps Milo escape the grip of criminal life, mob leader Tremolo rears his horned head toward Yahgie and challenges him to a rock-off! Pandora, Kazu, and the usual Hemlock Academy crew band together with Yahgie and his devil guitar, Mark Stevenson, for a heavy metal performance of epic proportions!