Over the last decade, technical advances have allowed genomic testing which provides a great opportunity for diagnosis but also an increased chance of uncertain or unexpected findings. This book addresses many of the questions that arise in this context and summarizes the essential concepts in diagnostic genetic testing in an easy-to-read manner. It also covers some broad context for the practical and ethical implications of examining human DNA sequences.The book starts with a gene...

The stories in Getting’ High take place mainly in New York City and Puerto Rico, though three are set in rural Michigan where the author grew up. They take place, by and large, during the turbulent decade of the 1960’s. As the title suggests, many characters smoke marijuana and experience its eerie, pleasurable effects. That is one current running through several stories, though not a major theme. Rather, the thematic anchor is the search for love and meaning in a changing, transient world...

Witness the ever-changing history and identity of America in this collection of 40 stories collected from the first 100 years of this bestselling series.For the centennial celebration of this annual series, The Best American Short Stories, master of the form Lorrie Moore selects forty stories from the more than two thousand that were published in previous editions. Series editor Heidi Pitlor recounts behind-the-scenes anecdotes and examines, decade by deca...

From the Pultizer Prize-winning author of ‘The Hours’, comes the story of a marriage thrown off course by a moment of mistaken identity.Peter Harris is forty-four, prosperous, the owner of a big New York apartment and a player in the contemporary art scene. He has been married to Rebecca for close to twenty years. Their marriage is sound, in the way marriages are. Peter might even describe himself as happy. But then Rebecca’s much younger brother Mizzy shows up for a visit. Beautif...

Robert McCammon, Norman Prentiss, Shawntelle Madison, Graham Masterton, and Richard Christian Matheson scale new heights of horror, suspense, and grimmest fantasy in Dark Screams: Volume Two, from Brian James Freeman and Richard Chizmar of the renowned Cemetery Dance Publications.THE DEEP END by Robert McCammonEveryone thinks the drowning death of Neil Calder in the local swimming pool was a tragic accident. Only his father knows better. Now, on the...

Living in the slums of Rio and eking out a living as a typist, Macabéa loves movies, Coca-Cola and her philandering rat of a boyfriend; she would like to be like Marilyn Monroe, but she is ugly and unloved. Yet telling her story is the narrator Rodrigo S.M., who tries to direct Macabéa's fate but comes to realize that, for all her outward misery, she is inwardly free. Slyly subverting ideas of poverty, identity, love and the art of writing itself, Clarice Lispector's audacious last novel i...

He is relentlessly defiant. He is exceedingly libidinous. His appetite for the outrageous is insatiable. He is Mickey Sabbath, the aging, raging powerhouse whose savage effrontery and mocking audacity are at the heart of Philip Roth's astonishing new novel. Sabbath's Theater tells Mickey's story in the wake of the death of his mistress, an erotic free spirit whose adulterous daring exceeds even his own. Once a scandalously inventive puppeteer, Mickey is now in his mid-sixties and besieged ...

'A work of near heroic vitality and cunning' Sunday TelegraphAt sixty-four Mickey Sabbath is still defiantly antagonistic and exceedingly libidinous; sex is an obsession and a principle, an instrument of perpetual misrule in his daily existence.But after the death of his long-time mistress - an erotic free spirit whose great taste for the impermissible matches his own - Sabbath embarks on a turbulent journey into his past. Bereft and grieving, torm...

T.E.D. Klein's highly acclaimed first novel The Ceremonies—which Stephen King called "the most exciting novel in my field to come along since Straub's Ghost Story—established him in the top rank of horror writers. Now, with the four novellas gathered here, Klein proves himself to be a master of this classic shorter form.The collection opens with "Children of the Kingdom", a beautifully crafted chiller that gradually reveals the horrors that lurk behind the shadows of the city. In "...

Lambda Literary Award-winning editor Richard Canning brings together all new work by Edmund White, Dale Peck, James McCourt, Andrew Holleran, and others.

GOOD MORNING AMERICA BUZZ PICK • The Pulitzer Prize–winning playwright and co-writer of In the Heights tells her lyrical story of coming of age against the backdrop of an ailing Philadelphia barrio, with her sprawling Puerto Rican family as a collective muse.“Quiara Alegría Hudes is in her own league. Her sentences will take your breath away. How lucky we are to have her telling our stories.”—Lin-Manuel Miranda, award-winning creator of

The Damned, one of many classic novels from crime writer John D. MacDonald, the beloved author of Cape Fear and the Travis McGee series, is now available as an eBook.At a ferry stop along the Rio Conchos, the line of cars waiting to cross stretches to the horizon. Because of a bureaucratic blunder, the boat has been stalled, with no relief in sight for the drivers—many of them American, many growing impatient to reach the border. That kind of tens...