Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less d...

This book investigates tradeoff between security and usability in designing leakage resilient password systems (LRP) and introduces two practical LRP systems named Cover Pad and ShadowKey. It demonstrates that existing LRP systems are subject to both brute force attacks and statistical attacks and that these attacks cannot be effectively mitigated without sacrificing the usability of LRP systems. Quantitative analysis proves that a secure LRP system in practical settings imposes a consider...

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students t...

Since the late 1970s China has undergone a great transformation, during which time the country has witnessed an outpouring of competing schools of thought. This book analyzes the major schools of political thought redefining China's transformation and the role Chinese thinkers are playing in the post-Mao era.

The U.S. has 400,000 lawyers in a society of 200 million people. China, a country with four times that population, has a mere 3,500 lawyers. How do the Chinese achieve law without lawyers? Victor Li, one of the world's leading authorities on Chinese law, explores the way the Chinese and U.S. systems have historically viewed law (and still view it), and the way each system functions in everyday life to shape conduct and control deviance. In a straightforward and highly readable manner, the ...

Advances in Plant Cold Hardiness provides a detailed, up-to-date discussion of plant cold hardiness research. The molecular mechanisms of plant cold hardiness development, a subject not covered in any other low temperature stress book, is examined in depth. Other major topics addressed include the freezing tolerance and injury of plant tissues in vivo and in vitro, in addition to how research findings impact agricultural applications. The articles featured in Advances in Plant Cold Hardine...

The importance of low temperature stress physiology research has become increasingly apparent in agriculture for productions of food, fibre and ornamental plants. This volume consists of two parts, there are a total of 14 chapters including 6 chapters dealing with cold accumulation related topics, 6 dealing with freeze stress and 2 related to ethylene production and mefluidide protection.

The Routledge Course in Chinese Media Literacy is aimed at lower advanced level students of Mandarin who wish to build media literacy in the Chinese language.The book is written by university professors who have hands-on experience as media professionals. It gathers newsworthy authentic materials on topics covered by reporters on a day-to-day basis, and makes them accessible through prereading exercises, grammatical analysis, vocabulary associations, and research training ...

Lab-on-a-chip technology permits us to make many important discoveries that can only be observed at the microscale or the nanoscale. Using this technology, biological and biochemical analyses translate into greater sensitivity, more accurate results, and more valuable findings. Authored by one of the field's pioneering researchers, Fundamentals of

Published in 1998, in this book the author points out the inadequacies caused by the division between housing research on production and consumption, and the theoretical divide between structural and agent-centred approaches on housing. By developing an understanding of social relations within the structured process of housing provision, the author argues that action and the specific form of housing provision can be better understood. By using pre-sale housing in Taiwan as a positive examp...

The microfluidic lab-on-a-chip allows scientists to conduct chemical and biochemical analysis in a miniaturized format so small that properties and effects are successfully enhanced, and processes seamlessly integrated. This microscale advantage translates into greater sensitivity, more accurate results, and better information. Microfluidic

Intestinal neoplasia comprises a large part of a surgical pathologist’s workload. Pathologists play a key role not only in the classification of malignancies but also in assisting screening programs, identifying incidental neoplasms, and guiding treatment by providing essential prognostic features for individual entities. A large variety of neoplasms affect the intestines, and there is ongoing discovery of new entities and prognostic features for known diseases. Pathologists and trainees s...