Based on decades of research centered on the earliest known fluted-point producing groups in the North American midcontinent, Early Paleoindians in the Upper Midcontinent of North America: Lithic Procurement, Settlement Mobility, and Social Interaction brings together a broad array of case studies from the United States and Canada that offers fresh perspectives on how early populations utilized the land and its resources, how and when they settled in particular locations, and how ...

The covalent conjugation of potent cytotoxic agents to monoclonal antibodies, known as antibody-drug conjugates (ADCs) is a powerful approach in the field of targeted treatment of cancer. Clearly, both monoclonal antibody and cytotoxic payload are crucial elements in determining the clinical value of an ADC and have receive ample attention. However, the structural element connecting the two –the chemical linker– also plays an essential role in mode-of-action, efficacy, pharmacokinetics and...

Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and ev...

Landscape ecology has emerged in the past decade as an important and useful tool for land-use planners and landscape architects. While professionals and scholars have begun to incorporate aspects of this new field into their work, there remains a need for a summary of key principles and how they might be applied in design and planning.This volume fills that need. It is a concise handbook that lists and illustrates key principles in the field, presenting specific examples of how the...

An impassioned case for the importance of ancient forests and their preservationStanding in an old-growth forest, you can instinctively sense the ways it is different from forests shaped by humans. These ancient, undisturbed ecosystems are increasingly rare and largely misunderstood. Nature’s Temples explores the science and alchemy of old-growth forests and makes a compelling case for their protection.Many foresters are proponents...

The Handbook of Cell Signaling is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The subject matter has been divided into five main parts (each of which is headed by a recognized expert in the field):* Initiation: Extracellular and Membrane Events* Transmission: Effectors and Cytosolic Events * Nuclear Responses: Gene ...

Richly illustrated and packed with numerous examples, this unique global perspective introduces wetland ecology from basic principles to advanced applications. Thoroughly revised and reorganised, this new edition of this prize-winning textbook begins with underlying causal factors, before moving on to more advanced concepts that add depth and context. Each chapter begins with an explanation of the basic principles covered, illustrated with clear examples. More difficult concepts and except...

Donald R. Prothero's science books combine leading research with first-person narratives of discovery, injecting warmth and familiarity into a profession that has much to offer nonspecialists. Bringing his trademark style and wit to an increasingly relevant subject of concern, Prothero links the climate changes that have occurred over the past 200 million years to their effects on plants and animals. In particular, he contrasts the extinctions that ended the Cretaceous period, which wiped ...

70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies.First book to address the discovery and development of antibody therapeutics in their entirety.Most chapters contain experimental data to illustrate the principles described in them.Authors provide detailed methodologies that readers can take away with them an...

Over 15,000 years ago, a band of hunter-gatherers became the first people to set foot in the Americas. They soon found themselves in a world rich in plants and animals, but also a world still shivering itself out of the coldest depths of the Ice Age. The movement of those first Americans was one of the greatest journeys undertaken by ancient peoples. In this book, David Meltzer explores the world of Ice Age Americans, highlighting genetic, archaeological, and geological evidence that has r...

An essential outline of the main facets of polypharmacology in drug discovery researchExtending drug discovery opportunities beyond the "one drug, one target" philosophy, a polypharmacological approach to the treatment of complex diseases is emerging as a hot topic in both industry and academic research. Polypharmacology in Drug Discovery presents an overview of the various facets of polypharmacology and how it can be applied as an innovative concept for developing medicines for tr...

Over the past two decades, the oil sands region of northeastern Alberta has been the site of unprecedented levels of development. Alberta's Lower Athabasca Basin tells a fascinating story of how a catastrophic ice age flood left behind a unique landscape in the Lower Athabasca Basin, one that made deposits of bitumen available for surface mining. Less well known is the discovery that this flood also produced an environment that supported perhaps the most intensive use of boreal fo...