Gerd B. Achenbach’s Philosophical Praxis: Origin, Relations, and Legacy, translated by Michael Picard, offers unique insights into the compelling origin and development of what has been called a renaissance of philosophy: a storied trove of thought steeped in tradition, character, and experience, and redeployed in the service of understanding the individual life. Throughout this book, the author explores Philosophical Praxis not only through the tumultuous history of philosophy, b...

Medical Risk Prediction Models: With Ties to Machine Learning is a hands-on book for clinicians, epidemiologists, and professional statisticians who need to make or evaluate a statistical prediction model based on data. The subject of the book is the patient’s individualized probability of a medical event within a given time horizon. Gerds and Kattan describe the mathematical details of making and evaluating a statistical prediction model in a highly pedagogical manner whi...

HMG-CoA reductase inhibitors (statins) are established drugs for the treatment of hypercholesterolemia. Furthermore, they induce regression of vascular atherosclerosis as well as reduction of cardiovascular-related morbidity and death in patients with and without coronary artery disease. This book deals with statins which have substantially altered the approach to therapy of atherosclerosis and its sequelae. Emphasis is placed on the scientific background to the discoveries and the develop...

Following an opening chapter by the late Susumu Ohno on paralogues of sex-determining genes, the five best-studied genes essential for early mammalian gonadal development are portrayed in detail: SF-1 and WT1 and their roles in early events in gonadal development, SRY and SOX9 in testis determination, and the anti-testis gene DAX-1. Subsequent chapters look at the roles of these genes in sex determination in marsupial mammals, birds, reptiles, amphibians and fish, and review the different ...

This book discusses the development of the Rosenbrock—Wanner methods from the origins of the idea to current research with the stable and efficient numerical solution and differential-algebraic systems of equations, still in focus. The reader gets a comprehensive insight into the classical methods as well as into the development and properties of novel W-methods, two-step and exponential Rosenbrock methods. In addition, descriptive applications from the fields of water and hydrogen network...

This book constitutes the proceedings of the 25th International Conference on Theory and Practice of Digital Libraries, TPDL 2021, held in September 2021. Due to COVID-10 pandemic the conference was held virtually.The 10 full papers, 3 short papers and 13 other papers presented were carefully reviewed and selected from 53 submissions. TPDL 2021 attempts to facilitate establishing connections and convergences between diverse research communities such as Digital Humanities, Informati...

The world's coastlines represent a myriad of dynamic and constantly changing environments. Heavily settled and intensely used areas, they are of enormous importance to humans and understanding how they are shaped and change is crucial to our future.Introduction to Coastal Processes and Geomorphologybegins by discussing coastal systems and shows how these systems link to the processes examined in detail throughout the book. These include the morphodynamic paradigm, tides, waves and ...

The Moment of Liberation in Western Europe: Power Struggles & Rebellions, 1943–1948, regards the final two years of World War II and the immediate post-liberation period as a moment in twentieth century history when the shape and contours of postwar Western Europe appeared highly uncertain and various alternatives and conflicting visions were up for grabs. After close to six years of total war, Nazi terror, and brutal occupation policies, a growing number of Europeans were no long...