This text provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in early prostate cancer. The book reviews new data about genetic markers, transperineal mapping biopsy and mpMRI, how to apply each of these technologies in patients with elevated PSA, when a prior prostate biopsy performed by the standard TRUS method is negative and in cases where low risk disease is already diagnosed, ...

Essentials of Surgical Pediatric Pathology is a clear and practical yet comprehensive guide for trainee pediatric pathologists and non-pediatric pathologists. Each chapter corresponds to one of the main subspecialties, such as dermatopathology, head and neck pathology, and system pathology. Practical guidance is given on handling pediatric specimens and the authors highlight the ways in which common conditions present differently in adults and children. Other chapters cover conditions typi...

As in volume 1 of this series, this volume presents information on stem cells and cancer stem cells; Therapeutic Applications in disease and tissue/organ injury. Methodologies of regenerative medicine and tissue engineering are major components of this volume. Specific stem cells discussed are: human embryonic stem cells, hematopoietic stem cells, cord blood stem cells, human pluripotent stem cells, gliosarcoma stem cells, induced pluripotent stem cells, intestinal stem cells, human thyroi...

Frozen sections are performed while a patient is undergoing surgery as a basis for making an immediate diagnosis that will impact treatment decisions. Frozen section diagnosis is often a highly demanding situation for the pathologist who must render a diagnosis quickly for the patient and surgeon.The Frozen Section Library series will provide concise, user-friendly, site specific handbooks that are well illustrated and highlight the pitfalls, artifacts and differential diagnosis is...

Aging represents a physiological and per se non-pathological and multifactorial process involving a set of key genes and mechanisms being triggered by different endogenous and exogenous factors. Since aging is a major risk factor in connection with a variety of human disorders, it is increasingly becoming a central topic in biochemical and medical research. The plethora of theories on aging – some of which have been discussed for decades – are neither isolated nor contradictory bu...

Researchers' knowledge of gliomas continues to advance rapidly at both the basic and translational levels, and Gliomas provides a thorough overview of the evolving fields of tumor biology and clinical medicine as they relate to our understanding of brain tumors. Gliomas reviews the current paradigms that underlie these fields, beginning with the molecular epidemiology of glioma susceptibility and prognosis through population-based science and genome-wide association studies. The book's dis...

Critical Care Neurology, Part II: Neurology of Critical Illness focuses on the care specialists and general neurologists that consult in the ICU and their work with patients in acute, life-threatening situations who are dealing with neurologic or neurosurgical crises emanating from either a preexisting neurologic syndrome or from a new neurologic complication appearing as a result of another medical or surgical critical illness. These two separate clinical situations form the pillars of ne...

This book provides a comprehensive account of the cellular pathology of glandular lesions and uncommon neoplasms of the cervix and places these in a contemporary clinical context. The book features comprehensive, detailed descriptions and a consistent approach to each tumor or tumor-like condition with clear color illustrations. Cytological/histological correlation is emphasised and diagnostic pitfalls are highlighted.Cellular Pathology of Glandular Lesions and Uncommon Neoplas...

Clinically accessible information for pathologists on histology, molecular pathology, differential diagnosis, and clinical overview is presented. Common and rare entities are covered with an abundance of images to highight key features.Topics for pathologists covering the fast moving field of breast pathology include: Less common variants and mimics of DCIS; Invasive lobular carcinoma and its variants; Important inflammatory and reactive lesions; Small glandular proliferations; Vascular le...

Breast cancer is the second leading cause of cancer death in women in the United States. For the pathologist, almost any breast lesion may produce diagnostic difficulty, especially due to frequently small samples (core biopsy specimens) and a variety of mimics and variants seen in specific types of lesions. Additionally, the difficulty of breast lesion diagnosis has risen dramatically in recent years due to the increased emphasis on stratifying patients for appropriate therapy on an indivi...

The data about different aneurysm locations given in the present work clearly demonstrate that the quality and the severity of the neuropsycho logical impairments after subarachnoid hemorrhage are in particular dependent on the anatomical location and extent of the bleeding. In addition, the sometimes inevitable temporary clipping of perforating vessels seems to play a significant role with respect to later neuropsychological disturbances. Since modern aneurysm surgery is performed in the ...