These are notes from a graduate student course on algebraic topology and K-theory given by Daniel Quillen at the Massachusetts Institute of Technology during 1979-1980. He had just received the Fields Medal for his work on these topics among others and was funny and playful with a confident humility from the start. These are not meant to be polished lecture notes, rather, things are presented as did Quillen reflected in the hand-written notes, resisting any temptation to change or add nota...