This book is intended for a broad readership, in particular, those working or interested in drug discovery coming from various disciplines such as medicinal chemistry, pharmacology, drug metabolism and pharmacokinetics, bioanalysis, clinical sciences, biochemistry, pharmaceutics, and toxicology. It provides, for the first time, a completely integrated look at multiple aspects of ADME sciences (absorption, distribution, metabolism, and excretion) in a summary format that is clear, concise, ...

Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical s...

Join creators, writers, and comics legends as they discuss the impact of Marvel Studios’ Black Panther in this gorgeously illustrated collection of essaysMarvel Studios’ Black Panther has become more than just a movie—it has shaped conversations about art, culture, science fiction, representation, justice, fashion, comics, creativity, and so much more. Celebrate the legacy of the film with this collection of all-new personal essays and reflections...

The Christology and Mystical Theology of Karl Rahner delineates what Rahner means by the mysticism of daily life, the mysticism of the masses, the mysticism of the classical masters, the difference between infused and awakened contemplation, the relation of mysticism to Christian perfection, and Rahner's controversial view that the mystical life does not require a special grace. It explores how Rahner embraces the person of Jesus Christ—whom Rahner sees as Christianity's center—both with h...

Concepts in Reproduction integrates the principal mechanisms of reproduction among eukaryotes, with a focus on animals and plants. The text emphasizes processes and approaches that evolved to address specific problems inherent in reproduction using examples from morphology, functional studies, and genetic studies. The many high-quality figures complement the text and provide visual storyboards. Footnotes and boxes are used throughout to provide depth and to enrich understanding. I...

DIE HOHE REPUBLIK Nach Jahren des Konflikts zwischen den Jedi und den Nihil kommt es auf dem Planeten Eriadu zur finalen Schlacht! Die Streitkräfte für Licht und Leben stehen dem Aufseher gegenüber, einem skrupellosen Kommandanten der Nihil, der fest entschlossen ist, den Planeten zu erobern. Die Jedi und ihre Verbündeten sind der Invasionsarmee zahlenmäßig weit unterlegen und müssen alles geben, um Eriadu vor den Nihil zu retten. Es folgt ein Kampf, der über das Schicksal der Galaxis ents...

Join creators, writers, and comics legends as they discuss the impact of Marvel Studios’ Black Panther in this wonderful collection of essaysMarvel Studios’ Black Panther has become more than just a movie—it has shaped conversations about art, culture, science fiction, representation, justice, fashion, comics, creativity, and so much more. Celebrate the legacy of the film with this collection of all-new personal essays and reflections that shed li...