The 2e of Molecular Diagnostics, the only book dealing with diagnosis on a molecular level, discusses current molecular biological techniques used to identify the underlying molecular defects in inherited disease. The book delves further into the principle and brief description of the technique, followed by examples from the authors' own expertise. Contributors to the 2e are well-known experts in their field, and derive from a variety of disciplines, to ensure breadth and depth of coverage...

AIDS and cancer are neither random nor infectious diseases. Both are characterized by a proton deficit and a reversal of the chimeric/energetic cooperative trend of the eukaryotic nucleus with the mitochondrial endosymbiont. This pattern is not random. It is consistent with the evolutionary heritage of the eukaryotic cell, which developed the foundational glycolytic pathways during the eon of the earths anaerobic-reducing atmosphere. It should no longer be a mystery that these primitive me...

Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements t...

Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine, all areas that have become critical steps in the successful development of marketable therapeutics. The text introduces the fundamental principles of drug discovery...

Drugs like Lipitor, Plavix, Taxol, and Zoloft are integral in today's medicinal world. These widely used products save lives and improve the quality of lives, playing a crucial role in everything from cholesterol management to cancer treatment. These advances in medicine were brought into existence after nuanced process of creation, featuring a wide range of chemical and pharmacological experimentation and discovery. Top Drugs: Their History, Pharmacology, and Synthesis provides a...

Gene therapy was conceived during the early and mid part of the 20th century. At first, it was considered a revolutionary biomedical procedure, which could potentially cure any disease for which the molecular bases were understood. Since then, gene therapy has gone through many stages and has evolved from a nearly unrealistic perspective to a real life application. Clinical efficacy in humans was demonstrated at the beginning of this century after its successful application in small-scale ...

Medicinal Chemistry is concerned with chemistry, synthesis, and structure activity relationships, mode of action and uses of drugs of carbon compounds. There are several books are available on medicinal chemistry, the material in most of them is present in a diffused form or highly specialized. In the ever expanding knowledge of the chemistry of drugs it is very difficult to go through the various textbooks, journals, and pharmacopoeias. Medicinal Chemistry has virtually widened the scope ...

Much of the biology of oxidative stress and oxidative signalling centres on the generation and handling of hydrogen peroxide. The overall aim for this book would be to provide an insightful and useful forum to assist with the understanding of the relevance of hydrogen peroxide generation and how this is managed in human biology. The target audience would be those who currently have an interest in the generation of ROS, but who do not have expertise in chemistry, as well as those experts in...

‘Hot Topics in Cell Biology’ is a definitive overview of the ‘state of the art’ in cell biology. It is based on papers presented by leading researchers at the Spanish Society for Cell Biology’s XIV Congress – a Congress that strives to achieve scientific excellence. Each participant was asked to prepare a ‘mini review’ of current and likely future development in their area of research. This book is based on those reviews. As such, it is therefore an analysis of current and future trends. Key ...

Lipids are the most abundant organic compounds found in the brain, accounting for up to 50% of its dry weight. The brain lipidome includes several thousands of distinct biochemical structures whose expression may greatly vary according to age, gender, brain region, cell type, as well as subcellular localization. In synaptic membranes, brain lipids specifically interact with neurotransmitter receptors and control their activity. Moreover, brain lipids play a key role in the generation and n...

This is the sixth set of Handbook of Porphyrin Science.This 5-volume set provides a comprehensive review of the most up-to-date research on porphyrin, heme and chlorophyll biochemistry, as well as applications to biomedicine and bio-inspired energy. In-depth coverage of topics along with perspectives on outstanding questions and future research directions by the authors make these volumes an essential resource for both beginning and advanced investigators in the field. It is also suitable ...