The book starts with an introduction to and history of myeloid-derived suppressor cells (MDSCs), followed by a description of their differentiation, their role in the tumour microenvironment and their therapeutic targeting. It closes with an outlook on future developments. In cancer patients, myelopoiesis is perturbed and instead of generating immunogenic myeloid cells (such as dendritic cells, inflammatory macrophages and granulocytes), there is an increase in highly immature MDSCs. These...

Winner of the 2016 MAGGIE AWARDFifty-five year old Jack Callahan has been alone, by choice, for five years.Forty-five year old Erica Thomas has never had a serious relationship and believes that love and marriage is not God's plan for her.Can a chance meeting in an airport and an impetuous photo change their destiny and prove that it's never too late to fall in love?