The purpose of this book is to examine the etiology of cancer in large human populations using mathematical models developed from an inter-disciplinary perspective of the population epidemiological, biodemographic, genetic and physiological basis of the mechanisms of cancer initiation and progression. In addition an investigation of how the basic mechanism of tumor initiation relates to general processes of senescence and to other major chronic diseases (e.g., heart disease and stroke) wil...

This volume is a critical exposition of the data and analyses from a full decade of rigorous research into how age-related changes at the individual level, along with other factors, contribute to morbidity, disability and mortality risks at the broader population level. After summarizing the state of our knowledge in the field, individual chapters offer enlightening discussion on a range of key topics such as age trajectory analysis in select and general populations, incidence/age patterns...

Statistics in Medicine, Third Edition makes medical statistics easy to understand by students, practicing physicians, and researchers. The book begins with databases from clinical medicine and uses such data to give multiple worked-out illustrations of every method. The text opens with how to plan studies from conception to publication and what to do with your data, and follows with step-by-step instructions for biostatistical methods from the simplest levels (averages, bar charts...

This book brings the power of multivariate statistics to graduate-level practitioners, making these analytical methods accessible without lengthy mathematical derivations. Using the open source, shareware program R, Professor Zelterman demonstrates the process and outcomes for a wide array of multivariate statistical applications. Chapters cover graphical displays, linear algebra, univariate, bivariate and multivariate normal distributions, factor methods, linear regressio...

Inverse Projection is a method for estimating accurate demographic indicators of a population where vital registration data are available, but population censuses are lacking or unreliable. The book offers an overview of the present state of methodological development in the field of inverse projection techniques. In the various chapters of the book, leading experts in demography and related fields review the method, discuss recent extensions, test performances, and stress differences of t...

Applied Survival Analysis Using R covers the main principles of survival analysis, gives examples of how it is applied, and teaches how to put those principles to use to analyze data using R as a vehicle. Survival data, where the primary outcome is time to a specific event, arise in many areas of biomedical research, including clinical trials, epidemiological studies, and studies of animals. Many survival methods are extensions of techniques used in linear regression and categoric...

This book details cutting-edge methods and findings that may shape the future of applied demography. Inside, readers will discover new insights into the databases, substantive issues, and methodological approaches that can help them to improve how they use demography in decision making and planning problems in both public and private settings.The topics and perspectives are found in the book’s 23 chapters, which are organized into three major sections: (I) Demographic Information f...

This book outlines 11 courses and 15 research topics in bioinformatics, based on curriculums and talks in a graduate summer school on bioinformatics that was held in Tsinghua University. The courses include: Basics for Bioinformatics, Basic Statistics for Bioinformatics, Topics in Computational Genomics, Statistical Methods in Bioinformatics, Algorithms in Computational Biology, Multivariate Statistical Methods in Bioinformatics Research, Association Analysis for Human Diseases: Methods an...

Over the past decades Europe has witnessed fundamental changes of its population dynamics and population structure. Fertility has fallen below replacement level in almost all European countries, while childbearing behavior and family formation have become more diverse. Life expectancy has increased in Western Europe for both females and males, but has been declining for men in some Eastern European countries. Immigration from non-European countries has increased substantially, as has mobil...

This timely text presents a comprehensive guide to genetic association, a new and rapidly expanding field that aims to elucidate how our genetic code (genotypes) influences the traits we possess (phenotypes). The book provides a detailed review of methods of gene mapping used in association with experimental crosses, as well as genome-wide association studies. Emphasis is placed on model selection procedures for analyzing data from large-scale genome scans based on specifically designed mo...

An ambitious global history that fundamentally alters our understanding of MalthusThe New Worlds of Thomas Robert Malthus is a sweeping global and intellectual history that radically recasts our understanding of Malthus's Essay on the Principle of Population, the most famous book on population ever written or ever likely to be. Malthus's Essay is also persistently misunderstood. First published anonymously in 1798, the Essay syst...

Numerical Ecology with R provides a long-awaited bridge between a textbook in Numerical Ecology and the implementation of this discipline in the R language. After short theoretical overviews, the authors accompany the users through the exploration of the methods by means of applied and extensively commented examples. Users are invited to use this book as a teaching companion at the computer. The travel starts with exploratory approaches, proceeds with the construc...