This book presents new mathematics for the description of structure and dynamics in molecular and cellular biology. On an exponential scale it is possible to combine functions describing inner organisation, including finite periodicity, with functions for outside morphology into a complete definition of structure. This mathematics is particularly fruitful to apply at molecular and atomic distances. The structure descriptions can then be related to atomic and molecular forces and provide in...

This monograph is a summary of observations collected over the past ten years on vagal denervation of the stomach and the functional pathology of the vagotomized stomach. It is primarily a continuation of the work we (Holle and Heinrich, 1954) began with fundectomy - the prototype of proximal dener vation of the stomach. This was the starting point for the develop ment of selective proximal vagotomy (SPV). Between 1961 and 1964 the SPY technique was developed to the extent that it could be...

This book develops the thesis that structure and function in a variety of condensed systems - from the atomic assemblies in inorganic frameworks and organic molecules, through molecular self-assemblies to proteins - can be unified when curvature and surface geometry are taken together with molecular shape and forces. An astonishing variety of synthetic and biological assemblies can be accurately modelled and understood in terms of hyperbolic surfaces, whose richness and beauty are only now...

In this thought-provoking book, Denis Noble formulates the theory of biological relativity, emphasising that living organisms operate at multiple levels of complexity and must therefore be analysed from a multi-scale, relativistic perspective. Noble explains that all biological processes operate by means of molecular, cellular and organismal networks. The interactive nature of these fundamental processes is at the core of biological relativity and, as such, challenges simplified molecular ...

Increasingly, wound management is recognised as a specialised area of practice. Advances in wound-care products, surgical interventions, and social-support options create an often bewildering array of knowledge for healthcare practitioners. This textbook opens with a focus on the core elements of effective wound management: an understanding of how wounds heal and what inhibits wound healing, rigorous assessment, use of outcome measures, evidence-based approaches to practice, and an underst...

In Nucleation in Condensed Matter, key theoretical models for nucleation are developed and experimental data are used to discuss their range of validity. A central aim of this book is to enable the reader, when faced with a phenomenon in which nucleation appears to play a role, to determine whether nucleation is indeed important and to develop a quantitative and predictive description of the nucleation behavior. The third section of the book examines nucleation processes in practical situa...

This is the fourth edition of the successful laboratory guide which has translated the rich story of riboneucleic acid for over fifteen years. RNA Methodologies 4e presents the latest collection of tested laboratory protocols for the isolation and characterization of eukaryotic and prokaryotic RNA with greater emphasis on transcript profiling, including quantification issues and elucidation of alternative transcription start sites. Collectively the chapters work together providing analysis...

Chemists are used to the operational definition of symmetry, which crystallographers introduced long before the advent of quantum mechanics. The ball-and-stick models of molecules naturally exhibit the symmetrical properties of macroscopic objects. However, the practitioner of quantum chemistry and molecular modeling is not concerned with balls and sticks, but with subatomic particles: nuclei and electrons.This textbook introduces the subtle metaphors which relate our macroscopic u...

Among the standard oncology modalities, surgical oncology is singular in that it lacks a separate board certification or even an added qualification mecha nism. 'Card-carrying' surgical oncologists are certified by the American Board of Surgery, as are all other general surgeons. What distinguishes the surgical oncologist is a set of cognitive skills rather than a specific armamentarium of surgical techniques. This different conceptual framework is derived from ex tensive additional traini...

Now in paperback, this book provides an overview of the physics of condensed matter systems. Assuming a familiarity with the basics of quantum mechanics and statistical mechanics, the book establishes a general framework for describing condensed phases of matter, based on symmetries and conservation laws. It explores the role of spatial dimensionality and microscopic interactions in determining the nature of phase transitions, as well as discussing the structure and properties of materials...

Fluorescent proteins are intimately connected to research in the life sciences. Tagging of gene products with fluorescent proteins has revolutionized all areas of biosciences, ranging from fundamental biochemistry to clinical oncology, to environmental research. The discovery of the Green Fluorescent Protein, its first, seminal application and the ingenious development of a broad palette of fluorescence proteins of other colours, was consequently recognised with the Nobel Prize for Chemist...

Trauma: A Comprehensive Emergency Medicine Approach is a fully illustrated, interdisciplinary overview of trauma. Using both evidence-based approaches and a practical understanding of the emergency department, it gives a broad and in-depth review of trauma care. The entire spectrum of trauma presentations is reviewed from minor soft-tissue injuries through to major life-threatening conditions. Written by over 50 expert contributors, it gives concrete and practical recommendations for evalu...