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Springer Protocols eBook Series

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  • SH2 Domains

    Functional Modules and Evolving Tools in Biology

    Edited by Teresa Carlomagno, Maja Köhn ...
    Series series Springer Protocols
    This volume looks at the latest methods used to study and modulate the biological function and mechanisms of SH2 domains. The chapters in this book are organized into five parts. Part One presents methodology aimed at determining the structures and dynamics of SH2 domains and their complexes with phosphopeptides. Part Two discusses techniques to understand and predict interactions of SH2 domains ... Read more

    PHP10,865.29

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  • Field-Flow Fractionation in Biopolymer Analysis

    Series series Chemistry and Material Science (R0)
    This is a timely collection of important biomedical applications for a set of separation/characterization techniques that are rapidly gaining popularity due to their wide dynamic range, high resolution, and ability to function in most commonly used solvent systems. Importantly, the field-flow fractionation (FFF) technique has recently emerged as a prominent complement to size exclusion ... Read more

    PHP9,041.89

  • Protein Liquid Chromatography

    by M. Kastner ...
    Series Book 61 - Journal of Chromatography Library
    Protein Liquid Chromatography is a handbook-style guide to liquid chromatography as a tool for isolating and purifying proteins, consisting of 25 individual chapters divided into three parts: Part A covers commonly-used, classic modes of chromatography such as ion-exchange, size-exclusion, and reversed-phase; Part B deals with various target protein classes such as membrane proteins, recombinant ... Read more

    PHP15,552.49

  • Biomolecular Forms And Functions: A Celebration Of 50 Years Of The Ramachandran Map

    Understanding the functions and properties of molecules in living systems requires a detailed knowledge of their three-dimensional structures and the conformational variability that allows them to adopt multiple functional forms. Interpreting biological systems in the language of three-dimensional structures is of fundamental importance and innumerable research groups around the world are working ... Read more

    PHP3,437.19

  • Disruption of Protein-Protein Interfaces

    In Search of New Inhibitors

    Edited by Stefano Mangani ...
    Series series Chemistry and Material Science (R0)
    "Disruption of Protein-Protein Interfaces" reviews the latest developments and future perspectives in drug discovery at protein-protein interfaces. The authors detail experimental and computational tools to tackle the subject and highlight the contribution of the Italian research community to the field. Evidence shows that blocking or modulating protein-protein interactions might lead to the ... Read more

    PHP5,812.49

  • Biophysics for Therapeutic Protein Development

    Edited by Linda O. Narhi ...
    Series series Biomedical and Life Sciences (R0)
    This book can be used to provide insight into this important application of biophysics for those who are planning a career in protein therapeutic development, and for those outside this area who are interested in understanding it better. The initial chapters describe the underlying theory, and strengths and weaknesses of the different techniques commonly used during therapeutic development. The ... Read more

    PHP9,041.89

  • Protein Instability at Interfaces During Drug Product Development

    Fundamental Understanding, Evaluation, and Mitigation

    Series series Biomedical and Life Sciences (R0)
    Proteins are exposed to various interfacial stresses during drug product development. They are subjected to air-liquid, liquid-solid, and, sometimes, liquid-liquid interfaces throughout the development cycle-from manufacturing of drug substances to storage and drug delivery. Unlike small molecule drugs, proteins are typically unstable at interfaces where, on adsorption, they often denature and ... Read more

    PHP5,812.49

  • Structural Genomics and Drug Discovery

    Methods and Protocols

    Edited by Wayne F. Anderson ...
    Series series Springer Protocols
    Structural Genomics and Drug Discovery: Methods and Protocols focuses on high throughput structure determination methods and how they can be applied to lay the groundwork for structure aided drug discovery. The methods and protocols that are described can be applied in any laboratory interested in using detailed structural information to advance the initial stages of drug discovery. Written in the ... Read more

    PHP6,458.39

  • RNA Structure and Dynamics

    Series series Springer Protocols
    This volume provides a wide spectrum of multidisciplinary approaches for studying RNA structure and dynamics, including detailed accounts of experimental and computational procedures. Chapters guide readers through cryo-electron microscopy, crystallography, isothermal titration calorimetry, small angle X-ray scattering, single-molecule Förster Energy transfer, X-ray free electron laser, atomic ... Read more

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  • The Next Generation in Membrane Protein Structure Determination

    Edited by Isabel Moraes ...
    Series series Biomedical and Life Sciences (R0)
    This book reviews current techniques used in membrane protein structural biology, with a strong focus on practical issues. The study of membrane protein structures not only provides a basic understanding of life at the molecular level but also helps in the rational and targeted design of new drugs with reduced side effects. Today, about 60% of the commercially available drugs target membrane ... Read more

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  • Nucleic Acid Aptamers

    Selection, Characterization, and Application

    Series series Springer Protocols
    This updated book reflects improvements in a variety of techniques used to study the aptamer field. Beginning with a section on selection procedures, the volume continues with methods to characterize aptamers’ interaction and structural properties by biophysical approaches, as well as a variety of applications that have been adapted to the aptamer compound class. Written for the highly successful ... Read more

    PHP6,458.39