Pharmacology meets the rapidly emerging needs of programs training pharmacologic scientists seeking careers in basic research and drug discovery rather than such applied fields as pharmacy and medicine. While the market is crowded with many clinical and therapeutic pharmacology textbooks, the field of pharmacology is booming with the prospects of discovering new drugs, and virtually no extant textbook meets this need at the student level. The market is so bereft of such approaches that man...

The best review of renal physiology available for USMLE Step 1--completely updated with the latest researchWritten in a clear, concise, logical style, this trusted text reviews the fundamental principles of the structure, function and pathologies of the human kidney that are essential for an understanding of clinical medicine. Combining the latest research with a fully integrated teaching approach, the eighth edition of Vander's Renal Physiology features revised sections...

Textbook of Pharmacoepidemiology, Second Edition, provides an introduction to pharmacoepidemiology and the data sources, methods and applications used in clinical research, the pharmaceutical industryand regulatory agencies.Drawing upon the fifth edition of the authoritative reference, Pharmacoepidemiology, this new edition covers the key learning requirements of the discipline. The textbook provides an introduction topharmacoepidemiology, pharmacoep...

The turbulent history of generic pharmaceuticals raises powerful questions about similarity and difference in modern medicine.Generic drugs are now familiar objects in clinics, drugstores, and households around the world. We like to think of these tablets, capsules, patches, and ointments as interchangeable with their brand-name counterparts: why pay more for the same? And yet they are not quite the same. They differ in price, in place of origin, in color, shape, a...

This first systematic treatment of the concept and practice of scaffold hopping shows the tricks of the trade and provides invaluable guidance for the reader's own projects.The first section serves as an introduction to the topic by describing the concept of scaffolds, their discovery, diversity and representation, and their importance for finding new chemical entities. The following part describes the most common tools and methods for scaffold hopping, whether topological, shape-b...

"The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies."—From the Afterword by Anthony D. DayanProper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching ...

Provides both fundamentals and new and emerging applicationsAdvanced Drug Delivery brings readers fully up to date with the state of the science, presenting the basics, formulation strategies, and therapeutic applications of advanced drug delivery. The book demonstrates how core concepts of pharmaceutical sciences, chemistry, and molecular biology can be combined and applied in order to spark novel ideas to design and develop advanced drug delivery systems for the treatmen...

The most complete and up-to-date text on the art and science of embalmingSponsored by the American Board of Funeral Service EducationComprehensive and thoroughly updated in this fifth edition, Embalming: History, Theory, and Practice is the leading text in the field. The trusted classic covers the long history of embalming, explains embalming theory, and describes present practice, including the latest trends.Speci...

Ivermectin and abamectin, members of the avermectin family of compounds, were introduced to the market in the 1980's as a veterinary antiparasitic drug and agricultural pesticide, respectively. Their acceptance and commercial success have been remarkable; both are highly effective and in worldwide use. The efficacy of ivermectin in river blindness has expanded the interest in its use in human medicine. In response to the intense scientific and industrial i...

In recent years, the fabrication of nanomaterials and exploration of their properties have attracted the attention of various scientific disciplines such as biology, physics, chemistry, and engineering. Although nanoparticulate systems are of significant interest in various scientific and technological areas, there is little known about the safety of these nanoscale objects. It has now been established that the surfaces of nanoparticles are immediately covered by biomolecules (e.g. protein...

This volume is dedicated to Professor Ullrich Trendelenburg. It contains the proceedings of a symposium which was held in his honour on the occasion of his retirement and took place March 22-24, 1991 in Wiirzburg. Ullrich Trendelenburg was the head of the Department of Pharmacology at Wiirzburg University from 1968 till the end of March 1991. He is famous internationally for his contributions to the physiology and pharmacology of the autonomic nervous system, and his impact on pharmacology...

The spectrum of cardiovascular disease affecting women in pregnancy and postpartum is changing and differs between countries. In the western world, the risk of cardiovascular disease in pregnancy has increased due to the increasing age at the first pregnancy and the worldwide obesity epidemic leading also to early diabetes and hypertension. In addition the treatment of congenital heart disease has improved leading to an increased number of women with residual heart disease reaching childbe...