This book constitutes the conference proceedings of the Second International Conference on Computational Intelligence and Network Security, ICCINS 2025 held in Raipur, India, during April 2-4, 2025.The 30 full papers were carefully reviewed and selected from 205 submissions. They were categorized under the following topical sections: Machine Learning and Computational Intelligence; Intelligent Networking and Communication Systems; Cybersecurity, Privacy, and System Design.