A growing body of research demonstrates the potential benefits of the administration of inositol isomers in the treatment of many different disorders, from reproductive to metabolic diseases.A Clinical Guide to Inositols discusses scientific evidence of inositol-based treatments in different clinical fields to provide clinicians with a practical guide to use inositol supplementation within pathological conditions. Each chapter covers a specific disorder and describes aspects of the applica...

The study of epigenetics, or how heritable changes in gene expression are regulated without modifying the coding DNA sequence, has become an increasingly important field of study in recent years. Rapid developments in our understanding of the way in which gene function is modulated by the environment has revolutionized the way we think about human development and health. Nutrition in Epigenetics reviews the latest research looking at the interaction between genes and nutrients and...

"A comprehensive guide for patients, families, and caregivers facing leukemia."Are you or a loved one facing a leukemia diagnosis? Arm yourself with knowledge, hope, and support with "Leukemia: A Comprehensive Guide to Understanding, Diagnosis, and Treatment."This essential guidebook provides a clear and thorough overview of leukemia, demystifying the complexities of this blood cancer for patients, families, and caregivers. Carefully written, this book help...

Developed as a one-stop reference source for drug safety and toxicology professionals, this book explains why mitochondrial failure is a crucial step in drug toxicity and how it can be avoided.• Covers both basic science and applied technology / methods• Allows readers to understand the basis of mitochondrial function, the preclinical assessments used, and what they reveal about drug effects• Contains both in vitro and in vivo methods for analysis, including practical...

Polycystic ovary syndrome (PCOS) is the most frequent disorder affecting women of reproductive age. Recent years have shown substantial advances in our understanding of the complex genetic, biochemical, metabolic, cardiovascular, and reproductive issues associated with PCOS. This book presents a comprehensive overview of recent clinical developments in identifying the phenotypic expression of women with PCOS resulting in a completely new recognition of its phenotypic variability. Metabolic...

Polycystic Ovary Syndrome discussesthe use of animal models in the study of PCOSthe occurrence of ovarian and adrenal abnormalities, cardiovascular risks, abnormal insulin secretion, and endothelial dysfunction in PCOSmodern therapeutic modalities, such as manipulation of diet and lifestyle, metabolic phenotyping

Epigenetics in Human Disease, Third Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. From molecular mechanisms and epigenetic technology to clinical translation of recent research, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics to t...

Understanding the influence and interaction between physical activity and the endocrine system are of paramount importance in dealing with a multitude of health problems. In Endocrinology of Physical Activity and Sport*, renowned physicians and researchers provide a comprehensive and expanded update on the scientific, clinical and practical components of endocrinology as related to sport and exercise. The authors thoroughly review what is known about how such activity effects the ...

This book is an up-to-date, extensive overview of the effects of physical activity and training on endocrine function. It gives insights into a complex relationship by describing effects with respect to exercise performance, growth, development, and ageing. It includes discussions of the endocrine response depending on exercise mode, intensity, and duration as well as on gender, age, and fitness level. Additionally the book deals with the impact of environmental and psychological factors o...

Defining and understanding cellular and molecular mechanisms that are relevant to women’s health has become a critical area of scientific pursuit. Until recently, very little effort has been place on defining or understanding critical differences between women and men that may be critical to the overall health of the woman. In 1990, the National Institutes of Health recognized this gap in knowledge resulting in the creation of the Office of Research on Women’s Health. One of the purposes o...

Nutrition and Epigenetics presents new information on the action of diet and nutritional determinants in regulating the epigenetic control of gene expression in health and disease. Each chapter gives a unique perspective on a different nutritional or dietary component or group of components, and reveals novel mechanisms by which dietary factors modulate the epigenome and affect development processes, chronic disease, and the aging process. This pivotal text:

DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as ...