Epigenetic Aspects of Chronic Diseases assembles in comprehensive form what is known about the role of epigenetics in chronic disease development. This book provides new insights into treatment, including modulation of epigenetic regulation. Each chapter gives an outline of a respective disease, explains why epigenetics may be involved in the disease process and then presents the evidence of how changes in epigenetic status contribute to initiation and progress of the disease. The final ch...

Recent research, which Bone- Metabolic Function and Modulators expands on, has added new support to the idea that bone not only serves as a support system, but also functions as an integrating organ, with a significant regulatory role for lipid and energy metabolism. Links between physical activity and the skeleton are also becoming increasingly clear. This fully illustrated volume contains up-to-date information on the metabolic role of the skeleton and what this can mean for the...

It has been several years since the nuclear medicine community was presented with an outstanding text on bone scintigraphy. Over a span of three decades the value of this enormously important clinical modality has remained undiminished, despite the introduction of new techniques for examining bone, especially magnetic re- nance imaging and positron emission tomography (PET). In fact the positron em- ting sodium fluoride-F-18 was employed as a bone imaging agent over 30 years ago and now fi...

When I was a young intern in internal medicine,osteoporosis was defined mainly as a fracture occurring in elderly people. However,although plain X-ray examination was recognized as an insensitive way to detect osteoporosis, hypodense bone was already considered as the reflection of the disease. Over the past 20 years, con siderable progress has been accomplished. In terms of prevalence, incidence, risk factors, and the burden of osteoporosis and low-energy fracture, we can appreciate the m...

The publication of a third edition after only five years confirms the widespread popularity of this book. Apart from the numerous additions and modifications consequent on the substantial expansion of knowledge in this field, the authors have further improved the value of this text with the excellent chapter, as men tioned in their preface, on general aspects of the problem. The advances referred to in this chapter, particularly molecular genetics and database access, have transformed the ...

This practice-oriented book, containing a wealth of high-quality ultrasound images, provides clear, concise, and complete coverage of the normal anatomy of the hand and wrist – tendons, nerves, and vascular structures – as well as the main pathologic conditions encountered in this area. The ultrasound images have been acquired with state of the art scanners and carefully labeled to facilitate recognition of each and every anatomic structure. Helpful comparison is also made with images and ...

Osteoporosis in Clinical Practice provides a concise review of the current knowledge of osteoporosis. It is aimed at the busy pratitioner who is increasingly involved in the management of osteoporosis and who wants accurate and practical answers to questions that arise in daily clinical practice. All the major aspects are covered including diagnosis, fractures, prevention and treatment. The chapters are written to be concise and each has been written by a recognised expert in the area to p...

In the past, radiographs of the hand have been described as the “skeleton’s calling card”, showing manifestations of many different diseases. As hand and wrist imaging has become increasingly sophisticated, this observation has become more true than ever. This is a comprehensive, up-to-date textbook on imaging of the hand and wrist. In the first part of the book, the various imaging techniques are discussed in detail. Individual chapters are devoted to radiography, ultrasound, CT, MRI and ...