An estimated 80 million people live with a neurodegenerative disease. That number is expected to increase rapidly as populations age, lifespans increase, and exposure to toxins rises. Despite decades of research and billions in funding, there are no medications that can slow, much less stop, the progress of these diseases. This is because diseases such as Parkinson's and Alzheimer's do not exist in biology. Yet, hundreds of clinical trials around the world are examining the potential of si...

Now in a fully revised and updated Second Edition, Practical Neurology Visual Review previously known as (Practical Neurology DVD Review) continues to be a powerful educational tool for mastering the clinical practice of neurologic diagnosis. The book opens new venues for teaching and learning the essentials of neurology by utilizing an interactive patient-based audiovisual electronic format. PLEASE NOTE: This version does not include access to the online videos and interactive review ques...

An estimated 80 million people live with a neurodegenerative disease, with this number expected to double by 2050. Despite decades of research and billions in funding, there are no medications that can slow, much less stop, the progress of these diseases. The time to rethink degenerative brain disorders has come.With no biological boundaries between neurodegenerative diseases, illnesses such as Parkinson's and Alzheimer's result from a large spectrum of biological abnormalities, ha...

Precision Medicine in Neurodegenerative Disorders, Part Two, Volume 193 in the Handbook of Clinical Neurology deals with the "How" in the reconfiguration of our approach to slow accelerated brain aging. The book rethinks animal models on which therapies are tested, outlines the progress and expected changes in biological subtyping efforts using lysosomal, endosomal, mitochondrial, immune dysregulation, and inflammatory mechanisms of disease pathophysiology, and the growing role of microbio...

With easy-to-read, high-yield coverage of essential information in neurology, Concise Neurology: A Focused Review is a practical, everyday reference for busy practitioners, fellows, residents, and students who need a rapid overview of a complex subject. The second edition has been almost entirely rewritten to stay current with recent developments in the field but retains its quick-reference format: an intuitively designed one- or two-page presentation of each topic to facilitate rapid revi...

This concise but comprehensive book will help interested readers in the health care professions to navigate their way through the jungle of movement disorders, including the potentially complex differential diagnosis and management. The different disorders are discussed in individual sections that explain how to examine the patient and recognize the disorder from its basic phenomenology, how to confirm a diagnosis, how to distinguish a particular disorder from related conditions, and how t...

Precision Medicine in Neurodegenerative Disorders, Part One, Volume 192 in the Handbook of Clinical Neurology deals with the "Why" in the approach to slow the progression of accelerated brain aging. This volume is intended to provide a scholarly background on the framework, basic science and conceptual pitfalls related to disease-modifying efforts in Parkinson's, Alzheimer's and other neurodegenerative disorders. Among topics covered are different models of precision medicine, the lumping-...

Parkinson's disease is no longer considered only a motor disorder. It has become evident that the pathological changes are broad, the progression seems to follow a pattern suggesting transynaptic transmission via templation of proteins in a prion-like fashion, and that these pathological changes usually antedate the motor symptoms by decades. This book emphasizes treatment options for Parkinson's disease, critically assessing pharmacologic and surgical interventions for all aspects of the ...