Scientists' views on what makes an experiment successful have developed dramatically throughout history. Different criteria for proper experimentation were privileged at different times, entirely new criteria for securing experimental results emerged, and the meaning of commitment to experimentation altered. In About Method, Schickore captures this complex trajectory of change from 1660 to the twentieth century through the history of snake venom research. As experiments with poiso...

Control is a key ingredient of scientific experimentation; arguably, an uncontrolled intervention or manipulation is not even a genuine experiment. Experiments in the life sciences, however, are notoriously difficult to control due to the complexity and variability of living things. This Element discusses general features of controlled experimentation, epistemic and practical aspects, and historical perspectives. It argues that controlled experimentation has a material-technical and a conc...

This open access book provides a historical treatment of scientific control in experimentation in the longue durée. The introduction distinguishes four related strands in the history of experimental control: the development of practices to stabilize experimental conditions; the career of the comparative design; the unfolding of methodological discussions about control practices and designs; and the history of the term “control”. Each chapter brings these distinctions to bear on specific hi...

This open access book provides a fresh perspective on analysis and synthesis across several areas of inquiry. The two operations form a primary basis of modern laboratory science, ranging from the spectrographic analysis used in practically every scientific discipline today, to the naming of entire disciplines, such as synthetic organic chemistry. Despite their acknowledged significance, however, the history of analysis, synthesis, and their relations over the longue durée is poorly unders...