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Exon Skipping and Inclusion Therapies

Methods and Protocols

Redigeret af Yusuke Echigoya, Rika Maruyama, Toshifumi Yokota ...

Serier serie Springer Protocols
This fully updated edition presents a collection of protocols reflecting the latest advancements in exon skipping and inclusion strategies. The book explores the design of antisense oligonucleotide therapies, in vitro and in vivo evaluation of exon skipping in Duchenne muscular dystrophy, enhancing exon skipping efficiency, as well as methods involving spinal muscular atrophy and other diseases. ... Læs mere

1.587,64 kr.

This fully updated edition presents a collection of protocols reflecting the latest advancements in exon skipping and inclusion strategies. The book explores the design of antisense oligonucleotide therapies, in vitro and in vivo evaluation of exon skipping in Duchenne muscular dystrophy, enhancing exon skipping efficiency, as well as methods involving spinal muscular atrophy and other diseases.
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RNA Interference (RNAi)

af Wiley ...

Serier serie Life Science Research Fundamentals
The 2006 Nobel Prize in Physiology or Medicine was awarded to Andrew Z. Fire and Craig C. Mello for their discovery of RNA interference (RNAi). RNAi is a biological process in which RNA molecules can silence (inhibit) or up- or down-regulate gene expression, typically by causing the destruction of specific messenger RNA (mRNA) molecules. This collection of articles begins with an introduction to ... Læs mere

220,49 kr.

The 2006 Nobel Prize in Physiology or Medicine was awarded to Andrew Z. Fire and Craig C. Mello for their discovery of RNA interference (RNAi). RNAi is a biological process in which RNA molecules can silence (inhibit) or up- or down-regulate gene expression, typically by causing the destruction of specific messenger RNA (mRNA) molecules. This collection of articles begins with an introduction to
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Antibiotics

Targets, Mechanisms and Resistance

Redigeret af Claudio O. Gualerzi, Letizia Brandi, Attilio Fabbretti, Cynthia L. Pon ...

Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed.Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic ... Læs mere

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Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed.Opening with a general introduction about antimicrobial drugs, their targets and the problem of antibiotic
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Translational Medicine

Molecular Pharmacology and Drug Discovery

Redigeret af Robert A. Meyers ...

Serier serie Advances in Molecular Biology and Medicine
This reference work gives a compete overview of the different stages of drug development using a translational approach. The book is structured in different parts, following the different stages in drug development. Almost half of the work is dedicated to core of drug discovery using a translational approach, the identification of appropriate targets and screening methods for the identification of ... Læs mere

2.535,24 kr.

This reference work gives a compete overview of the different stages of drug development using a translational approach. The book is structured in different parts, following the different stages in drug development. Almost half of the work is dedicated to core of drug discovery using a translational approach, the identification of appropriate targets and screening methods for the identification of
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Chemistry and Pharmacology of Drug Discovery

Redigeret af Jie Jack Li ...

Case studies of 20 successful FDA-approved drugs, from biological rationale to clinical efficacy studies and state-of-the-art applicationsChemistry and Pharmacology of Drug Discovery illustrates how chemistry, biology, pharmacokinetics, and a host of disciplines come together to produce successful medicines, discussing a total of 20 drugs that are all FDA-approved post 2021—some of which are first ... Læs mere

1.137,36 kr.

Case studies of 20 successful FDA-approved drugs, from biological rationale to clinical efficacy studies and state-of-the-art applicationsChemistry and Pharmacology of Drug Discovery illustrates how chemistry, biology, pharmacokinetics, and a host of disciplines come together to produce successful medicines, discussing a total of 20 drugs that are all FDA-approved post 2021—some of which are first
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Protein Therapeutics

af Raimund Mannhold, Gerd Folkers, Helmut Buschmann ...

Serier serie Methods & Principles in Medicinal Chemistry
In this practice-oriented two volume handbook, professionals from some of the largest biopharmaceutical companies and top academic researchers address the key concepts and challenges in the development of protein pharmaceuticals for medicinal chemists and drug developers of all trades.Following an introduction tracing the rapid development of the protein therapeutics market over the last decade, ... Læs mere

1.997,61 kr.

In this practice-oriented two volume handbook, professionals from some of the largest biopharmaceutical companies and top academic researchers address the key concepts and challenges in the development of protein pharmaceuticals for medicinal chemists and drug developers of all trades.Following an introduction tracing the rapid development of the protein therapeutics market over the last decade,
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Bispecific Antibodies

Methods and Protocols

Redigeret af Masahiro Yasunaga ...

Serier serie Springer Protocols
This volume explores protocols and perspectives for the design, production, characterization, functional evaluation, and clinical translation of bispecific antibodies (BsAbs). Beginning with a variety of platforms for generating BsAbs, the book continues with sections covering protocols to evaluate T-cell-dependent bispecific antibodies, modeling and simulation approaches to support clinical ... Læs mere

1.512,99 kr.

This volume explores protocols and perspectives for the design, production, characterization, functional evaluation, and clinical translation of bispecific antibodies (BsAbs). Beginning with a variety of platforms for generating BsAbs, the book continues with sections covering protocols to evaluate T-cell-dependent bispecific antibodies, modeling and simulation approaches to support clinical
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Immune Homeostasis

Methods and Protocols

Redigeret af Vijay Kumar ...

Serier serie Springer Protocols
This volume discusses different aspects of immune homeostasis regulation and its dysregulation during various diseases, including infections, cancers, neurodegenerative diseases, autoinflammation, autoimmune diseases, and immunodeficiency, along with immunological, genetic, cell biology, and molecular biology techniques designed to understand immune homeostasis at different stages. The chapters in ... Læs mere

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This volume discusses different aspects of immune homeostasis regulation and its dysregulation during various diseases, including infections, cancers, neurodegenerative diseases, autoinflammation, autoimmune diseases, and immunodeficiency, along with immunological, genetic, cell biology, and molecular biology techniques designed to understand immune homeostasis at different stages. The chapters in
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Protein Phosphorylation in Parasites

Novel Targets for Antiparasitic Intervention

af Paul M. Selzer ...

Serier serie Drug Discovery in Infectious Diseases
This is the first book to collect and summarize in one publication the efforts to use kinases or phosphatases for drug development against parasite infections.The editors and contributors comprise the Who is Who in the field, and they are comprehensive in covering every aspect of the topic, from basic research findings to translational approaches in drug developmentThe result will be welcomed by ... Læs mere

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This is the first book to collect and summarize in one publication the efforts to use kinases or phosphatases for drug development against parasite infections.The editors and contributors comprise the Who is Who in the field, and they are comprehensive in covering every aspect of the topic, from basic research findings to translational approaches in drug developmentThe result will be welcomed by
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Engineering and Application of Pluripotent Stem Cells

Redigeret af Ulrich Martin, Robert Zweigerdt, Ina Gruh ...

Serier Bog 163 - Advances in Biochemical Engineering/Biotechnology
This book reviews the latest biotechnological advances with pluripotent stem cells, exploring their application in tissue engineering and medicinal chemistry. Chapters from expert contributors cover topics such as the production of transgene-free induced pluripotent stem cells (iPSCs), expansion, controlled differentiation and programming of pluripotent stem cells, and their genetic instability. ... Læs mere

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This book reviews the latest biotechnological advances with pluripotent stem cells, exploring their application in tissue engineering and medicinal chemistry. Chapters from expert contributors cover topics such as the production of transgene-free induced pluripotent stem cells (iPSCs), expansion, controlled differentiation and programming of pluripotent stem cells, and their genetic instability.
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Signaling by Toll-Like Receptors

Redigeret af Gregory W. Konat ...

The discovery of toll-like receptors (TLRs) spurred the field of innate immunity into a renaissance after many years of neglect. Since then, TLR research has grown at an exponential rate. Taking an integrated methodological approach, Signaling by Toll-Like Receptors offers a comprehensive review of important techniques in molecular biology, ... Læs mere

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The discovery of toll-like receptors (TLRs) spurred the field of innate immunity into a renaissance after many years of neglect. Since then, TLR research has grown at an exponential rate. Taking an integrated methodological approach, Signaling by Toll-Like Receptors offers a comprehensive review of important techniques in molecular biology,
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Cancer and Zebrafish

Mechanisms, Techniques, and Models

Redigeret af David M. Langenau ...

Serier serie Biomedical and Life Sciences (R0)
This volume focuses on defining the unique attributes of using the zebrafish cancer model for discovering important pathways and potential drug targets for the treatment of human cancers. Using the zebrafish model, the volume explores oncogene and tumor suppressor discovery, chemical genetic approaches, genomics, epigenetics, cancer imaging, and cell transplantation. Contributed chapters come from ... Læs mere

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This volume focuses on defining the unique attributes of using the zebrafish cancer model for discovering important pathways and potential drug targets for the treatment of human cancers. Using the zebrafish model, the volume explores oncogene and tumor suppressor discovery, chemical genetic approaches, genomics, epigenetics, cancer imaging, and cell transplantation. Contributed chapters come from
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Exon Skipping and Inclusion Therapies

Personer, der læser dette, syntes også om...

RNA Interference (RNAi)

Antibiotics

Translational Medicine

Chemistry and Pharmacology of Drug Discovery

Protein Therapeutics

Bispecific Antibodies

Immune Homeostasis

Protein Phosphorylation in Parasites

Engineering and Application of Pluripotent Stem Cells

Signaling by Toll-Like Receptors

Cancer and Zebrafish