This book can be first considered as a complete synthesis of the EcCoGen ANR project (2011-2012), involving researchers from different French labs (including MAP) and domains, breaking major difficulties of the real-time generative design in the early stages of a pre-architectural project. Then the scope becomes larger, and the authors introduce major prospects following recent advances on natural and artificial evolution.

Including case studies of macrocyclic marketed drugs and macrocycles in drug development, this book helps medicinal chemists deal with the synthetic and conceptual challenges of macrocycles in drug discovery efforts.Provides needed background to build a program in macrocycle drug discovery –design criteria, macrocycle profiles, applications, and limitationsFeatures chapters contributed from leading international figures involved in macrocyclic drug discovery efforts...