Antimicrobial agents are essential for the treatment of life-threatening infections and for managing the burden of minor infections in the community. In addition, they play a key role in organ and bone marrow transplantation, cancer chemotherapy, artificial joint and heart valve surgery. Unlike other classes of medicines, they are vulnerable to resistance from mutations in target microorganisms, and their adverse effects may extend to other patients (increased risk of cross-infection). As ...

Examining meningitis mainly from a bacterial perspective, but also including an overview of viral, fungal and chronic meningitis, this book describes the anatomy of the meninges and clinical signs and symptoms of this disease. Individual organisms that cause meningitis worldwide are dealt with in specific chapters, describing in detail how these pathogens interact with the human host at both a molecular and cellular level. The book provides a thorough understanding of bacterial virulence f...

Pharmaceutics: Basic Principles and Application to Pharmacy Practice is an engaging textbook that covers all aspects of pharmaceutics with emphasis on the basic science and its application to pharmacy practice. Based on curricular guidelines mandated by the American Council for Pharmacy Education (ACPE), this book incorporates laboratory skills by identifying portions of each principle that can be used in a clinical setting. In this way, instructors are able to demonstrate their adherence ...

Intensive care is a rapidly changing area of medicine, and after four years from the 2nd edition the volume editors and authors have deemed necessary to update it. In the recent years, in fact, five new randomised controlled trials and five new meta-analyses demonstrate that selective decontamination of the digestive tract [SDD] is an antimicrobial prophylaxis to prevent severe infections of not only lower airways but also of blood. Additionally, SDD has been shown to reduce inflammation i...

Provides both fundamentals and new and emerging applicationsAdvanced Drug Delivery brings readers fully up to date with the state of the science, presenting the basics, formulation strategies, and therapeutic applications of advanced drug delivery. The book demonstrates how core concepts of pharmaceutical sciences, chemistry, and molecular biology can be combined and applied in order to spark novel ideas to design and develop advanced drug delivery systems for the treatmen...

A new companion study guide to the most respected text in pharmacy educationGoodman & Gilman’s Workbook for Pharmacologic Therapeutics delivers concise, high-yield summaries of the world-renowned coverage of the actions and uses of therapeutic agents in relation to physiology and pathophysiology found in Goodman & Gilman’s The Pharmacological Basis of Therapeutics.In order to maximize the learning and teaching experience, this uni...

Vaccination is one of the most efficient and cost effective methods of promoting human health and has been in clinical use for at least 200 years. Nevertheless, infectious diseases continue to constitute a constant threat to the well being of humanity. Common pathogens, once believed to be under control, acquire increased virulence and resistance to drugs, while exotic microorganisms emerged from hidden reservoirs to cause yet incurable diseases in humans. These changes, together with epid...

Reasoning in terms of molecular recognition may be traced back to Emil Fischer, who practiced the art of chemistry at Humboldt University in Prussian Berlin a century ago. Today, it is clearly recognized that molecular recognition impacts and determines all life processes. It has become a key research field in both chemistry and biology and the emerging interface of what now is being called "chemical biology". The technological advances derived from this knowledge are particularly importan...

These are the proceedings of the third Asian Pacific Adalat Symposium. The first was held in Tokyo in 1982 and the second in Sydney in 1985. We were honoured that the late Dr. Sukaman and his colleagues were able to host this third symposium in Jakarta. This meeting was designed to contribute to and to promote international collaboration in cardiovascular research, and to help promote further knowledge and understanding about the treatment of vascular disease in the Asian Pacific area. Nif...

This book was conceived from a simple question as to why cancer is so difficult to treat. Ultimately we want to find ways to cure cancers, but that may be an elusive dream at least with the technologies we have now and expect to have in the near future. This leads the question of whether it is possible to improve current cancer treatment methods, especially from the perspective of enhancing targeted drug delivery to tumors. This volume is designed to provide information related to the diff...

This volume focuses on antibiotics research, a field of topical significance for human health due to the worrying increase of nosocomial infections caused by multi-resistant bacteria. It covers several basic aspects, such as the evolution of antibiotic resistance and the influence of antibiotics on the gut microbiota, and addresses the search for novel pathogenicity blockers as well as historical aspects of antibiotics. Further topics include applied aspects, such as drug discovery based o...

Cell Culture Methods for in vitro Toxicology introduces the reader to a range of techniques involved in the use of in vitro cell culture in toxicological studies. It deals with major cell types studied in the field of toxicology and will be useful for anyone wishing to start work with animal cell cultures or to refresh their knowledge relating to in vitro cell models. Fundamental chapters deal with the general biology of cytotoxicity and cell immortalisation thes...