Sequential Experimentation in Clinical Trials: Design and Analysis is developed from decades of work in research groups, statistical pedagogy, and workshop participation. Different parts of the book can be used for short courses on clinical trials, translational medical research, and sequential experimentation. The authors have successfully used the book to teach innovative clinical trial designs and statistical methods for Statistics Ph.D. students at Stanford University. There a...

Prediction models are important in various fields, including medicine, physics, meteorology, and finance. Prediction models will become more relevant in the medical field with the increase in knowledge on potential predictors of outcome, e.g. from genetics. Also, the number of applications will increase, e.g. with targeted early detection of disease, and individualized approaches to diagnostic testing and treatment. The current era of evidence-based medicine asks for an individualized appr...

This is the fifth edition of a very successful textbook on clinical trials methodology, written by recognized leaders who have long and extensive experience in all areas of clinical trials. The three authors of the first four editions have been joined by two others who add great expertise. A chapter on regulatory issues has been included and the chapter on data monitoring has been split into two and expanded. Many contemporary clinical trial examples have been added. There is much new mate...

Functional magnetic resonance imaging (fMRI) has become the most popular method for imaging brain function. Handbook of Functional MRI Data Analysis provides a comprehensive and practical introduction to the methods used for fMRI data analysis. Using minimal jargon, this book explains the concepts behind processing fMRI data, focusing on the techniques that are most commonly used in the field. This book provides background about the methods employed by common data analysis packages includi...

This highly anticipated second edition features new chapters and sections, 225 new references, and comprehensive R software. In keeping with the previous edition, this book is about the art and science of data analysis and predictive modelling, which entails choosing and using multiple tools. Instead of presenting isolated techniques, this text emphasises problem solving strategies that address the many issues arising when developing multi-variable models using real data and not standard t...

Praise for the Third Edition“. . . an easy-to read introduction to survival analysis which covers the major concepts and techniques of the subject.” —Statistics in Medical ResearchUpdated and expanded to reflect the latest developments, Statistical Methods for Survival Data Analysis, Fourth Edition continues to deliver a comprehensive introduction to the most commonly-used methods for analyzing survival data. Authored by a uniquely well-qualified ...

Praise for the First Edition". . . [this book] should be on the shelf of everyone interested in . . . longitudinal data analysis."—Journal of the American Statistical AssociationFeatures newly developed topics and applications of the analysis of longitudinal dataApplied Longitudinal Analysis, Second Edition presents modern methods for analyzing data from longitudinal studies and now features the latest state...

Numerical Ecology with R provides a long-awaited bridge between a textbook in Numerical Ecology and the implementation of this discipline in the R language. After short theoretical overviews, the authors accompany the users through the exploration of the methods by means of applied and extensively commented examples. Users are invited to use this book as a teaching companion at the computer. The travel starts with exploratory approaches, proceeds with the construc...

This textbook provides an introduction to the free software Python and its use for statistical data analysis. It covers common statistical tests for continuous, discrete and categorical data, as well as linear regression analysis and topics from survival analysis and Bayesian statistics. Working code and data for Python solutions for each test, together with easy-to-follow Python examples, can be reproduced by the reader and reinforce their immediate understanding of the topic. With recent...

This book is for anyone who has biomedical data and needs to identify variables that predict an outcome, for two-group outcomes such as tumor/not-tumor, survival/death, or response from treatment. Statistical learning machines are ideally suited to these types of prediction problems, especially if the variables being studied may not meet the assumptions of traditional techniques. Learning machines come from the world of probability and computer science but are not yet widely used in biomed...

This sophisticated package of statistical methods is for advanced master's (MPH) and PhD students in public health and epidemiology who are involved in the analysis of data. It makes the link from statistical theory to data analysis, focusing on the methods and data types most common in public health and related fields. Like most toolboxes, the statistical tools in this book are organized into sections with similar objectives. Unlike most toolboxes, however, these tools are accompanied by ...

This book provides an essential introduction to the field of dynamical models. Starting from classical theories such as set theory and probability, it allows readers to draw near to the fuzzy case. On one hand, the book equips readers with a fundamental understanding of the theoretical underpinnings of fuzzy sets and fuzzy dynamical systems. On the other, it demonstrates how these theories are used to solve modeling problems in biomathematics, and presents existing derivatives and integral...