Precision medicine is a rapidly-evolving field in the management of cancer. The use of novel molecular or genetic signatures in local-regional management is still in its infancy. Precision Radiation Oncology demystifies this state-of-the-art research and technology.By describing current existing clinical and pathologic features, and focusing on the ability to improve outcomes in cancer using radiation therapy, this book discusses incorporating novel genomic- or biology-bas...

A story too secret, too terrifying—and too shockingly intimate—for Victorian eyes.A note to the EditorDear Henry,I have been Simon Feximal’s companion, assistant and chronicler for twenty years now, and during that time my Casebooks of Feximal the Ghost-Hunter have spread the reputation of this most accomplished of ghost-hunters far and wide.You have asked me often for the tale of our first meeting, and how my association with Fexim...

Landing a minor part in the Empire Theatre Eastbourne's Christmas production of Cinderella, Charles Paris soon discovers that his main role is to gently introduce the show's baffled American star, Kenny Polizzi, to the bizarre customs of English pantomime. During their sessions in the local pub, Charles finds himself increasingly caught up in Polizzi's tangled affairs. But Charles is about to be far more involved than he might wish when he stumbles across a body beneath Eastbourne Pier. As...

Having landed a small part in a new West End play, The Habit of Faith, Charles Paris is dismayed to discover that his good fortune has been orchestrated by his bête noire, the now-famous screen actor Justin Grover. But why has Grover become involved in this relatively obscure production – and why has he roped in Charles to star? From the outset the production is fraught with difficulties – and matters become even more complicated when a body is discovered at the foot of the dressing room s...

“I want you all out—gone—dead—exterminated!” Alex Household had cried when, after a lifetime of struggle, he lost the starring role in a new play to an actor who couldn’t remember his lines. But did that mean that it was Alex who had shot the leading man dead during his climactic speech? Charles Paris, for one, could see many logical suspects, from the devious producer, to the gullible playwright, to the young starlet’s overprotective mother.But before Charles Paris, our middle-age...

Simon Brett's oldest and most beloved character, Charles Paris, is back. Paris, the often out-of-work actor, has a good part, for a change, playing Sir Toby Belch in a summer festival production of Twelfth Night. But when the director takes ill and then Paris' friend in the production is the apparent victim of intentional food poisoning meant for Paris, it's not long until the bodies start to turn up. Paris is forced to deal not only with a wild young director whose idea of Shakes...

Charles Paris, middle-aged actor turned amateur sleuth, is vacationing at a small English seaside town. Irresistibly drawn to anything theatrical, Charles seeks entertainment at the local music hall and endures a series of not-so-wonderful vaudeville acts in the hope that the man given star billing will be worth watching. This performer, Bill Peaky, comes on stage with his electric guitar, grasps the microphone—and drops dead, due to faulty wiring of the stage equipment.It looks li...

Simon Wells breathtaking account of life and murder with Manson and The Family, charting the influence of The Beatles, The Beach Boys and the Black Panthers on their enduring legacy of horror.

Charles Paris has landed a role in a lavish West-End musical. The star, one of England’s most popuar comedians, is adored by the public but despised in the business. He also seems to be behind some strange happenings backstage, including the rehearsal pianist being shot in the hand and an actor falling and breaking his leg. Why would the star want to sabotage his own show?The playwright wants to strangle him. The leading lady longs to stab him in the back. The young Lothario looks ...

The creator of the Hunchback of Notre Dame, Henry VIII and Captain Bligh, Charles Laughton's career spans 50 films and 40 stage roles. This entralling biography follows him from his parents' hotel in Scarborough to his climactic assumption of the role of King Lear in Statford at the end of his life. Along the way we meet a galaxy of Hollywood greats - from Korda, Hitchcock and Billy WIlder to Gregory Peck, Robert Mitchum and Marilyn Monroe. We also discover a hugely talented and complex ma...

Bill Nighy returns as the actor and amateur sleuth, Charles ParisBored, broke and reduced to baring all as a life model, Charles Paris is relieved to land a role in a new sitcom – even if it is woefully unfunny. But no sooner has filming begun than things start to go wrong. First a charmless PA dies in a freak accident, then the young, cocksure director bites the dust. Once again, Charles finds himself on the case, hunting for clues from a host of showbiz suspects ...

This eBook is the fourth in a series and serves as a companion and guide to the pioneering book, Understanding Laughter and Humor: Why We Laugh, Why We Don't, and Why It Matters, published by Palgrave Macmillan. Inside, readers will learn how to use the Mutual Vulnerability Theory of Laughter to comprehend and appreciate cognitive humor—instances when memory, problem-solving, and decision-making abilities fall short of that which might be considered "normal." Such shortcomings oft...