In these highly competitive times, there is little room for firms that are content to remain as they've always been. Global competition, commoditisation, legal outsourcing and pressure from clients to cut costs have created a sense of urgency within law firms to better understand their own businesses. This has implications for the way law firms view and use their resources, expertise and human capital. A commitment to innovation opens doors for law firms to better align themselves with cli...

This book aims to compile typical fundamental-to-advanced statistical methods to be used for health data sciences. Although the book promotes applications to health and health-related data, the models in the book can be used to analyze any kind of data. The data are analyzed with the commonly used statistical software of R/SAS (with online supplementary on SPSS/Stata). The data and computing programs will be available to facilitate readers’ learning experience. There has been considerable ...

Review of the First Edition:The authors strive to reduce theory to a minimum, which makes it a self-learning text that is comprehensible for biologists, physicians, etc. who lack an advanced mathematics background. Unlike in many other textbooks, R is not introduced with meaningless toy examples; instead the reader is taken by the hand and shown around some analyses, graphics, and simulations directly relating to meta-analysis… A useful hands-on guide for practitio...

To harness the high-throughput potential of DNA microarray technology, it is crucial that the analysis stages of the process are decoupled from the requirements of operator assistance. Microarray Image Analysis: An Algorithmic Approach presents an automatic system for microarray image processing to make this decoupling a reality. The proposed syste

This book will enable researchers and students of analysis to more easily understand research papers in which probabilistic methods are used to prove theorems of analysis, many of which have no other known proofs. The book assumes a course in measure and integration theory but requires little or no background in probability theory. It emplhasizes topics of interest to analysts, including random series, martingales and Brownian motion.

Now viewed as its own scientific discipline, clinical trial methodology encompasses the methods required for the protection of participants in a clinical trial and the methods necessary to provide a valid inference about the objective of the trial. Drawing from the authors' courses on the subject as well as the first author's more than 30 years wor

Review of the First Edition"The goal of this book, as stated by the authors, is to fill the knowledge gap that exists between developed statistical methods and the applications of these methods. Overall, this book achieves the goal successfully and does a nice job. I would highly recommend it …The example-based approach is easy to follow and makes the book a very helpful desktop reference for many biostatistics methods."—Journal of Statistical Software...

Vorweg Goethe: "Alles Lyrische muss im Ganzen sehr vernünftig, im Einzelnen ein bißchen unvernünftig sein" Der Inhalt besteht aus teils gereimten lyrischen Versen in hochdeutscher und einigen in plattdeutscher Sprache, ostfriesisches Platt. Einige Themen werden allegorisch oder metaphorisch behandelt, andere direkt. Politik, gesellschaftliche Besonderheiten und Bedingungen. Spöttische Verse halten uns den Spiegel vor. Een Hand vull Reit Wechselspiel Drömers Themenwechsel Moderspraak I, II ...

Using time-to-event analysis methodology requires careful definition of the event, censored observation, provision of adequate follow-up, number of events, and independence or "noninformativeness" of the censoring mechanisms relative to the event. Design and Analysis of Clinical Trials with Time-to-Event Endpoints provides a thorough presentation o

Interval-Censored Time-to-Event Data: Methods and Applications collects the most recent techniques, models, and computational tools for interval-censored time-to-event data. Top biostatisticians from academia, biopharmaceutical industries, and government agencies discuss how these advances are impacting clinical trials and biomedical research.Divid

Japan’s Household Registration System (koseki seido) is an extremely powerful state instrument, and is socially entrenched with a long history of population governance, social control and the maintenance of social order. It provides identity whilst at the same time imposing identity upon everyone registered, and in turn, the state receives validity and legitimacy from the registration of its inhabitants. The study of the procedures and mechanisms for identifying and documenting pe...

What good is a rattlesnake? What purpose do animals serve? All species play a vital role in their biological communities, and the removal of just one can have a noticeable and catastrophic ripple effect.Yet social and political pressures frequently pit species conservation against economic progress and prosperity, and scientists fear that we may be in the midst of a mass extinction event. Brian R. Chapman and William I. Lutterschmidt make the case that the effort to preserve animal...