This issue of Immunology and Allergy Clinics, edited by Dr. Pascal Demoly, is devoted to Drug Hypersensitivity. Articles in this issue include: Drug allergy diagnosis; Principles of drug allergy management: acute drug reactions, individual preventive measures, desensitization, general preventive measures; Antibiotics allergy; Non-steroidal anti-inflammatory drugs HS; Local and general anesthetics allergy; Radiocontrast media and dyes allergy; Chemotherapeutic agents allergy; Vaccine allerg...

Normally, our bodies have been naturally programmed from birth to begin going to sleep as soon as we lie down and close our eyes, but when our sleep pattern has been badly interrupted by insomnia, it can be difficult to quiet the mind, and stop the constant barrage of thought from running incessantly, so we can drift off to a comfortable, relaxing and deep sleep.The longer our sleep pattern is interrupted by insomnia, the more difficult it is to get back to a normal restful sleepin...

Electronic publishing and electronic means of text and data presentation have changed enormously since the first edition of this book was published in 1997. The third edition of Scientific Papers and Presentations applies traditional principles to today's modern techniques and the changing needs of up-and-coming academia. Topics include designing visual aids, writing first drafts, reviewing and revising, communicating clearly and concisely, adhering to stylistic principles, presenting data...

Now in its 17th Edition, Medications and Mothers’ Milk, is the worldwide best selling drug reference on the use of medications in breastfeeding mothers. This book provides you with the most current, complete, and easy-to-read information on thousands of medications in breastfeeding mothers.This massive update has numerous new drugs, diseases, vaccines, and syndromes. It also contains new tables, and changes to hundreds of existing drugs.Written by a world-renown cl...

Management of antibiotic therapy is one of the most complex and important areas in medicine. Once the clinician has selected an antimicrobial to use, this guide provides all the essential information required to administer the antimicrobial safely and effectively: dosing schedules, side effects/toxicity, drug-drug interactions, use in renal failure, hepatic dysfunction, pediatrics and pregnancy, and recommendations for breastfeeding. The information is organized in a visually attractive, u...

Many Healthcare workers must deal on a daily basis with the transportation, preparation, storage, clean up, and disposal of cytotoxic drugs, which are used in chemotherapy because of their harmful effect on cancer cells. These drugs also have harmful effects on good cells, and they therefore pose a significant health risk to those who work with them. Yet there is little safety and health information available about them, and what information is available is scattered across a vast array of...

This issue of Immunology and Allergy Clinics of North America, Guest Edited by Amy D. Klion, MD and Princess U. Ogbogu, MD, is devoted to Eosinophil-Associated Disorders. Drs. Klion and Ogbogu have assembled a group of expert authors to review the following topics: Evaluation and Differential Diagnosis of Persistent Marked Eosinophilia; Spectrum of Eosinophilic End Organ Manifestations; Eosinophilia in GI disorders; Eosinophilia in Hematologic Disorders; Eosinophilia in Rheumatologic/Vascu...

This issue of Immunology and Allergy Clinics, devoted to Obesity and Asthma, is edited by Dr. Anurag Agrawal. Articles in this issue include: Clinical Implications of the Obese Asthma Phenotypes; Childhood Obesity and the Risk of Allergy; Metabolic Asthma: Is there a link between obesity, asthma, and diabetes?; Role of Weight Management in Obese-Asthma Control; Obesity and Airway Disease: A Bioenergetic Problem?; Nutrition, Obesity, and Asthma: Exploring Epigenetic Programming; Obesity and...

Good Clinical Practice For Your Reference - Book 4  ICH - Clinical Safety E1 - E2F  ICH-E1 The Extent of Population Exposure to Assess Clinical Safety for Drugs Intended for Long-term Treatment of Non-Life-Threatening Conditions  ICH-E2A Clinical Safety Data Management: Definitions and Standards for Expedited Reporting  ICH-E2B(R2) Clinical Safety Data Management : Data Elements for Transmission of...

Topics in this clinically focused publication devoted to Anticoagulants are: Antithrombin clinical applications and anti-inflammatory effects; Pharmacology and laboratory testing of oral direct thrombin inhibitor Dabigatran; Pharmacology and laboratory testing of the oral Xa inhibitors; Clinical use of the new oral anticoagulants; Pharmacology and safety of new oral anticoagulants-the challenge of bleeding; Emergency reversal of Warfarin anticoagulation - prothrombin complex concentrate co...

ICH - Safety Guidelines S1A – S9  S1A Guideline on the Need for Carcinogenicity Studies  S1B Testing for Carcinogenicity of Pharmaceuticals  S1C(R2) Dose Selection for Carcinogenicity Studies of Pharmaceuticals  S2(R1) Guidance on Genotoxicity Testing and Data Interpretation for Pharmaceuticals Intended for Human Use  S3A Note for Guidance on Toxicokinetics: The Assessment of Systemic Exposure in Toxi...

E6 Good Clinical Practice  Guidance for Industry Part 11, Electronic Records; Electronic Signatures — Scope and Application  CFR 21-- General Part 11, Electronic Records; Electronic Signatures  21 CFR PART 50 Protection Of Human Subjects  21 CFR Part 54 Financial Disclosure By Clinical Investigators  21 CFR PART 56 Institutional Review Boards  Title 21 PART 312 Investigational New Drug Application  ICH E2A Clinica...