This book discusses the topic of the HLA antigen system. Chapters discuss topics such as; animal studies, the possible mechanisms of HLA and disease associations, statistical and genetic considerations, the clinical use of HLA typing, as well as the current status of HLA and disease associations.

Immunological Tolerance: A Reassessment of Mechanisms of the Immune Response presents the basic biological phenomena of immunological tolerance. This book discusses immunology as a critical field for the analysis of molecular features of mammalian cell genetics, biosynthesis, differentiation, and interactions among cell types. Organized into six chapters, this book begins with an overview of the relationship between antigen structure and its ability to induce tolerance. This text then exam...

Catching Cancer introduces readers to the investigators who created a medical revolution—a new way of looking at cancer and its causes. Featuring interviews with notable scientists such as Harald zur Hausen, Barry Marshall, Robin Warren, and others, the book tells the story of their struggles, their frustrations, and finally the breakthroughs that helped form some of the most profound changes in the way we view cancer. Claudia Cornwall takes readers inside the lab to reveal the long and wi...

Systemic Lupus Erythematosus, Fourth Edition, provides an understanding of the basic mechanisms as well as the diagnostic and therapeutic aspects of lupus. Four-color illustrations throughout, this book is attractive to both the investigative community and clinicians. As lupus has become a paradigm for the study of autoimmune disease, immunologists investigating autoimmunity are becoming more interested in lupus. Basic immunology of phospholipid antibodies, clotting abnorm...

Molecular Biology, Second Edition, introduces the basic concepts of molecular biology while incorporating primary literature from today's leading researchers. This new edition reflects the massive surge in our understanding of the molecular foundations of genetics, thanks to major scientific revolutions in genetics and computer technology. It explains how living organisms function at a molecular level and how DNA, RNA, and proteins interact to provide the cell with genetic information. Thi...

Innate immunity is one the most evolutionally conserved systems, designed to protect the organism from viruses and bacterial infections, stress and many other types of attacks from the outside world. During the past decade, the capacity of molecular biology and information technology to produce and analyse data have grown exponentially, rapidly reforming many aspects of immunology research in the post-genomics era. As a result, scientific understanding of signalling networks governing the ...

The Heart in Systemic Autoimmune Diseases, Second Edition, provides an overview on our current understanding of major complications relating to the heart and autoimmune diseases. It includes the latest information on the new pathogenetic mechanisms involved, along with clinical manifestations of these important comortbidities. Mortality in autoimmune diseases, in particular, rheumatoid arthritis and SLE, has increased when compared with the general population. This excess mortality is larg...

Rapid progress in analytical methods, within the past few decades, has led to the widespread applications of newer immunological and radioimmunoassay techniques to the diagnosis and treatment of hemorrhagic and thrombotic disorders. Major advances were made to meet the multiple challenges of improving precision, accuracy, and availability of various measurements. These advances have been paralleled by the discoveries of a close relationship between biological activities and the absolute co...

Volume 6 provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Attention is given to a number of mechanistic advances in the understanding of regulation, particularly the importance of nutrient availability; microRNAs; and cross-talk with other protein degradation pathways. Intracellular pathogen repurposing of autophagy for pathogenic benefit is also provided, ...

Platelets, Second Edition is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or ar...

This book features the most cutting-edge work from the world’s leading laboratories in this field and provides practical methods for differentiating pluripotent stem cells into hematopoietic lineages in the blood system. Pluripotent stem cells have attracted major interest from a fast-growing and multidisciplinary community of researchers who are developing new techniques for the derivation and differentiation of these cells into specific cell lineages. These direct differentiation methods...