The covalent conjugation of potent cytotoxic agents to monoclonal antibodies, known as antibody-drug conjugates (ADCs) is a powerful approach in the field of targeted treatment of cancer. Clearly, both monoclonal antibody and cytotoxic payload are crucial elements in determining the clinical value of an ADC and have receive ample attention. However, the structural element connecting the two –the chemical linker– also plays an essential role in mode-of-action, efficacy, pharmacokinetics and...

Based on decades of research centered on the earliest known fluted-point producing groups in the North American midcontinent, Early Paleoindians in the Upper Midcontinent of North America: Lithic Procurement, Settlement Mobility, and Social Interaction brings together a broad array of case studies from the United States and Canada that offers fresh perspectives on how early populations utilized the land and its resources, how and when they settled in particular locations, and how ...

The major contribution made by Coastal Forces to the Allied war effort has had surprisingly little coverage in the literature of the Second World War. Motor torpedo boats, PT boats, motor gunboats, launches and submarine chasers served with distinction throughout the War, and in every theatre. They performed invaluable service as patrol boats, convoy escorts, minelayers and minesweepers, harbour defence vessels, light landing craft, RAF rescue boats and transports for agents and clandestin...

The first volume is devoted to Canada, the second to the United States. Lambert landed at Quebec in October 1806. He furnishes a picture of the place of that date, and describes the social manners, dress and political events which were happening, with more than the usual care bestowed by the passing traveller. Much of his historical narrative, however, is not in accordance with fact, having been disproved by authentic document . From Quebec he visited Three Rivers and Montreal, and ascendi...

"Fields of Light" is a collection of noetic prose, poems and song poems inspired by John Lambert's near-death experience at age 19. The collection is punctuated with references to mythical and mystical traditions that emphasize the transcendent in our humanness. From the I Ching to Frances Bacon, John's use of language playfully invites readers to open themselves to the goodness and beauty within and around them. "Fields of Light" is a lyrical exploration of the spirituality each of us can...

It's sometimes difficult for those of us steeped in the comforts and ease of today’s modern world to grasp what a life of radical faith can look like. What was ministry like for missionaries living a hundred years ago? What happened "back in the day" when brave missionary pioneers forsook all to follow the calling of God into completely unknown territories? How did God’s faithfulness sustain them?This collection of 24 short stories of missionary adventures from around the globe is ...

The major contribution made by Coastal Forces to the Allied war effort has had surprisingly little coverage in the literature of the Second World War. Motor torpedo boats, PT boats, motor gunboats, launches and submarine chasers served with distinction throughout the War, and in every theatre. They performed invaluable service as patrol boats, convoy escorts, minelayers and minesweepers, harbour defence vessels, light landing craft, RAF rescue boats and transports for agents and clandestin...

The first volume is devoted to Canada, the second to the United States. Lambert landed at Quebec in October 1806. He furnishes a picture of the place of that date, and describes the social manners, dress and political events which were happening, with more than the usual care bestowed by the passing traveller. Much of his historical narrative, however, is not in accordance with fact, having been disproved by authentic document . From Quebec he visited Three Rivers and Montreal, and ascendi...

Julia In The Rain: In Every Heart There's A Melody is a captivating, melodic piano piece composed by John Lambert Harman. It is written in the classical/romantic musical style. The piece has a length of 158 bars, and can be performed in its entirety or until bar 127-suitable for the intermediate or advanced pianist. Taken from the project 'Music For Films And The Outside'.

This reference text presents a conceptual framework for understanding room-temperature electron and phonon transport through molecules and other quantum objects. The flow of electricity through molecules is explained at the boundary of physics and chemistry, providing an authoritative introduction to molecular electronics for physicists, and quantum transport for chemists.Professor Lambert provides a pedagogical account of the fundamental concepts needed to understand quantum trans...

All of us, whatever our age, are in a fishing boat, trying to catch something. Catch what? It might be knowledge, or money, or happiness ‒ or simply finding out how to have a great life. Of course there are a lot of other possibilities.Here are three fishing boats, all heading in the right direction, prepared to catch something special.*The first boat has a crew of one. A young person fishing on their own.*The second fishing boat has a family for the crew.

Leo’s dead-end job in telephone support leaves him scraping by in a cramped city apartment, until coworkers point him toward Manhattan Talent, a prestigious agency promising high pay and fame with no experience required. A quick, anonymous photo submission changes everything.An AI-driven audition reveals more than just potential as a model or actor—it uncovers a long-buried truth about his body and identity. Guided by compassionate mentors, Leo embarks on a courageous path of explo...