An argument that technology accelerates biological discovery, with case studies ranging from chromosome discovery with early microscopes to how DNA replicates using radioisotope labels.Engineering has been an essential collaborator in biological research and breakthroughs in biology are often enabled by technological advances. Decoding the double helix structure of DNA, for example, only became possible after significant advances in such technologies as X-ray diffr...

Life is an enduring mystery. Yet, science tells us that living beings are merely sophisticated structures of lifeless molecules. If this view is correct, where do the seemingly purposeful motions of cells and organisms originate? In Life's Ratchet, physicist Peter M. Hoffmann locates the answer to this age-old question at the nanoscale.Below the calm, ordered exterior of a living organism lies microscopic chaos, or what Hoffmann calls the molecular storm -- specialized mol...

“Venter instills awe for biology as it is, and as it might become in our hands.” —Publishers WeeklyOn May 20, 2010, headlines around the world announced one of the most extraordinary accomplishments in modern science: the creation of the world’s first synthetic lifeform. In Life at the Speed of Light, scientist J. Craig Venter, best known for sequencing the human genome, shares the dramatic account of how he led a team of researchers in this pione...

A Nobel Prize–winning biologist’s “engaging and witty” (Forbes) memoir tells the riveting story of his race to discover the inner workings of biology’s most important moleculeEveryone has heard of DNA. But by itself, DNA is just an inert blueprint for life. It is the ribosome—an enormous molecular machine made up of a million atoms—that makes DNA come to life, turning our genetic code into proteins and therefore into us. Gene Machine is an insider...

**From the renowned biochemist and author of The Vital Question, an illuminating inquiry into the Krebs cycle and the origins of life.“Nick Lane’s exploration of the building blocks that underlie life’s big fundamental questions—the origin of life itself, aging, and disease—have shaped my thinking since I first came across his work. He is one of my favorite science writers.”—Bill Gates**What brings the Earth to life, and our own lives to an end?For decades,...

Candid, provocative, and disarming, this is the widely-praised memoir of the co-discoverer of the double helix of DNA.

Drawn from the pages of Scientific American and collected here for the first time, this work contains updated and condensed information, made accessible to a general popular science audience, on the subject of understanding the genome.

Everyone has heard of the story of DNA as the story of Watson and Crick and Rosalind Franklin, but knowing the structure of DNA was only a part of a greater struggle to understand life's secrets. Life's Greatest Secret is the story of the discovery and cracking of the genetic code, the thing that ultimately enables a spiraling molecule to give rise to the life that exists all around us. This great scientific breakthrough has had farreaching consequences for how we understand ourse...

The processes in a single living cell are akin to that of a city teeming with molecular inhabitants that move, communicate, cooperate, and compete. In this Very Short Introduction, Philip Ball explores the role of the molecule in and around us - how, for example, a single fertilized egg can grow into a multi-celled Mozart, what makes spider's silk insoluble in the morning dew, and how this molecular dynamism is being captured in the laboratory, promising to reinvent chemistry as the centra...

Synthetic Biology — A Primer gives a broad overview of the emerging field of synthetic biology and the foundational concepts on which it is built. It will be of interest to final year undergraduates, postgraduates and established researchers who are interested in learning about this exciting new field. The book introduces readers to fundamental concepts in molecular biology and engineering and then explores the two major themes for synthetic biology, namely ‘bottom-up’ and ‘top-down’ engin...

After more than fifty years of blockbuster drug development, skeptics are beginning to fear we are reaching the end of drug discovery to combat major diseases. In this engaging book, Brent R. Stockwell, a leading researcher in the exciting new science of chemical biology, describes this dilemma and the powerful techniques that may bring drug research into the twenty-first century.Filled with absorbing stories of breakthroughs, this book begins with the scientific achievements of th...

Physical Biology of the Cell is a textbook for a first course in physical biology or biophysics for undergraduate or graduate students. It maps the huge and complex landscape of cell and molecular biology from the distinct perspective of physical biology. As a key organizing principle, the proximity of topics is based on the physical concepts that