The ideal way to develop sound judgment about data applicable to clinical careFirst choice of students, educators, and practitionersA thorough, meaningful, and interesting presentation of biostatisticsHelps students become informed users and consumers of biostatisticsLearn to evaluate and apply statistics in medicine, medical research, and all health-related fields.Emphasis on the basics of biostatistics and ep...

This text is intended for a broad audience as both an introduction to predictive models as well as a guide to applying them. Non-mathematical readers will appreciate the intuitive explanations of the techniques while an emphasis on problem-solving with real data across a wide variety of applications will aid practitioners who wish to extend their expertise. Readers should have knowledge of basic statistical ideas, such as correlation and linear regression analysis. While the text is biased...

Epidemiology Kept Simple introduces the epidemiological principles and methods that are increasingly important in the practice of medicine and public health. With minimum use of technical language it fully explains terminology, concepts, and techniques associated with traditional and modern epidemiology. Topics include disease causality, epidemiologic measures, descriptive epidemiology, study design, clinical and primary prevention trials, observational cohort studies, case-contro...

This advanced textbook is tailored for an introductory course in Systems Biology and is well-suited for biologists as well as engineers and computer scientists.It comes with student-friendly reading lists and a companion website featuring a short exam prep version of the book and educational modeling programs. The text is written in an easily accessible style and includes numerous worked examples and study questions in each chapter. For this edition, a section on medical systems bi...

This volume features selected contributions on a variety of topics related to linear statistical inference. The peer-reviewed papers from the International Conference on Trends and Perspectives in Linear Statistical Inference (LinStat 2016) held in Istanbul, Turkey, 22-25 August 2016, cover topics in both theoretical and applied statistics, such as linear models, high-dimensional statistics, computational statistics, the design of experiments, and multivariate analysis. The book is intende...

This book provides an essential introduction to the field of dynamical models. Starting from classical theories such as set theory and probability, it allows readers to draw near to the fuzzy case. On one hand, the book equips readers with a fundamental understanding of the theoretical underpinnings of fuzzy sets and fuzzy dynamical systems. On the other, it demonstrates how these theories are used to solve modeling problems in biomathematics, and presents existing derivatives and integral...

This is the first book in longitudinal categorical data analysis with parametric correlation models developed based on dynamic relationships among repeated categorical responses. This book is a natural generalization of the longitudinal binary data analysis to the multinomial data setup with more than two categories. Thus, unlike the existing books on cross-sectional categorical data analysis using log linear models, this book uses multinomial probability models both in cross-sectional and...

Very little has been published on optimization of pharmaceutical portfolios. Moreover, most of published literature is coming from the commercial side, where probability of technical success (PoS) is treated as fixed, and not as a consequence of development strategy or design. In this book there is a strong focus on impact of study design on PoS and ultimately on the value of portfolio. Design options that are discussed in different chapters are dose-selection strategies, adaptive design a...

This book describes various ways of approaching and interpreting the data produced by clinical trial studies, with a special emphasis on the essential role that biostatistics plays in clinical trials.Over the past few decades the role of statistics in the evaluation and interpretation of clinical data has become of paramount importance. As a result the standards of clinical study design, conduct and interpretation have undergone substantial improvement. The book includes 18 careful...

Stochastic Orders in Reliability and Risk Management is composed of 19 contributions on the theory of stochastic orders, stochastic comparison of order statistics, stochastic orders in reliability and risk analysis, and applications. These review/exploratory chapters present recent and current research on stochastic orders reported at the International Workshop on Stochastic Orders in Reliability and Risk Management, or SORR2011, which took place in the City Hotel, Xiamen, China, ...