Animal Physiologic Surgery presents an integrated approach to the study of surgery for first-year medical students and graduate students in physiology. The primary emphasis is on the interrela tionships between surgical techniques and physiologic phenomena observed before, during, and after surgery. All procedures described in the book are designed so that the student with a limited knowledge of surgery can successfully assume responsibility for pre- and postoperative care, as well as for ...

The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood–brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barr...

The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood –brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS bar...