Indonesia is an exotic and exciting place to live. This an entertaining collection of experiences and observations from an Englishman who lived, loved, and drank beer, quite a lot of it, in the country for twenty years. Most of the articles first appeared in a local English-language magazine, but this collection contains the 'ones that got away' and weren't published because the editor wished to avoid ruining the readers' breakfast, upsetting the advertisers, or being trolled by animal lov...

A practical introduction to epidemiology, biostatistics, and research methodology for the whole health care communityThis comprehensive text, which has been extensively revised with new material and additional topics, utilizes a practical slant to introduce health professionals and students to epidemiology, biostatistics, and research methodology. It draws examples from a wide range of topics, covering all of the main contemporary health research methods, including...

With the remarkable expansion in the use of antipsychotics, concerns about their immediate, intermediate, and long-term adverse effects have intensified. Despite this, studies consistently show that monitoring of patients taking antipsychotics can be inadequate, haphazard, or worse. This book provides a comprehensive review of the adverse effects of this pharmacologically complex therapeutic class, covering all commonly used conventional and atypical agents. In the first section, each chap...

Cancer therapeutics include an ever-increasing array of tools at the disposal of clinicians in their treatment of this disease. However, cancer is a tough opponent in this battle, and current treatments, which typically include radiotherapy, chemotherapy and surgery, are not often enough to rid the patient of his or her cancer. Cancer cells can become resistant to the treatments directed at them, and overcoming this drug resistance is an important research focus. Additionally, increasing d...

Medical education — the art and science behind medical teaching and learning — has progressed remarkably. Teaching and learning have become more scientific and rigorous, curricula are based on sound pedagogical principles, and problem-based and other forms of active and self-directed learning have become the mainstream. We have progressed from the role of problem-identifier to that of solution-provider.This book provides a balanced overview of the ';why'; of medical education, emphasizing ...

The polysomnogram is a formidable sleep medicine tool, typically incorporating multiple channels of physiologic data including EEG, ECG, EMG, respiratory flow and effort, ventilation via CO2 monitoring, oxygen saturation via pulse oximetry and ventilatory treatment modalities. Aspiring experts must constantly ask themselves questions regarding PSG interpretation such as: Am I confident in using all of these modalities? Can I accurately and consistently distinguish a seizure from a movement...

Global Clinical Trials for Alzheimer's Disease is a handy one-stop reference for researchers and physicians planning and conducting global clinical trials in this area. This book addresses important considerations that may arise during the successful design and execution of these trials, including site selection, local regulatory issues, pharmacogenomics, ethical matters and much more. Given the saturation of traditional clinical trial markets and the worldwide progression of Alzheimer's d...

This book provides practical guidance to emergency personnel and others in the event of having to manage individual or mass chemical casualties as part of their work in a civilian ambulance service or hospital. The text considers the nature and basic science of the hazards faced as well as the practical management of persons exposed to chemicals and toxins (which although of biological origin behave as chemicals in terms of their effects and transmission).Individual chapters cover ...

Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980’s with its identification as an effector of phorbol esters, natural products with tumor promoting activity. Phorbol esters had long been of interest to the cancer research field due to early studies in the mouse skin carcinogenesis model, which showed that prolonged topical application of phorbol esters promoted the formation of skin tumors on mice previous...

The volume ‘Appetite Control’ provides a comprehensive description of the mechanisms controlling food intake, and thereby energy balance, in the mammalian organism. During the last decade, research in this area has produced a remarkable wealth of information and has characterized the function of numerous peptides, transmitters, and receptors in appetite control. Dysfunction of these circuits leads to obesity, a growing health concern. However, the plethora of mechanistic information is in ...

Fosfomycin is an antimicrobial substance which is available since several years. In earlier clinical studies an oral preparation with poor absorption in a low dosage resulted in inadequate therapeutic results. The presently used parenteral administration in a dosage range of up to 250 mg/kg BW however allowed us to appreciate several unique properties of this drug which make it valuable in the treatment of serious bacterial infections. Due to its small molecular weight and complete lack of...

The availability of analgesics and non-steroidal anti-inflammatory drugs (NSAIDs) sold over-the-counter (OTC) to the public without prescription has become an issue of major concern in recent years. The problem has been highlighted in the UK, USA and other countries because of the continuing high rates of cases of poisoning and the influence of switching from prescription-only status for many NSAIDs to OTC sale brought about, in a large part, by governments and health maintenance organisat...