This second edition expands upon and updates the vital research covered in its predecessor, by presenting state-of-the-art multidisciplinary and systems-oriented approaches to complex diseases arising from and driven by the acute inflammatory response. The chapters in this volume provide an introduction to different types of computational modeling, and how these methods can be applied to specific inflammatory diseases, with a focus on providing readers a roadmap for integrating advanced ma...

Are we satisfied with the rate of drug development? Are we happy with the drugs that come to market? Are we getting our money's worth in spending for basic biomedical research? In Translational Systems Biology, Drs. Yoram Vodovotz and Gary An address these questions by providing a foundational description the barriers facing biomedical research today and the immediate future, and how these barriers could be overcome through the adoption of a robust and scalable approach that will form the ...

The difficulty in achieving effective translation of basic mechanistic biomedical knowledge into effective therapeutics, is the greatest challenge in biomedical research. Nowhere is this more apparent than in the reductionist approaches to understanding and manipulating the acute inflammatory response in the settings of sepsis, trauma/hemorrhage, wound healing, and related processes. This book discusses complex systems and computational biology methods and approaches that have advanced suf...

A powerful sixth book in the horror anthology series which Booklist called "Highly recommended for longstanding horror fans and those readers who may not think horror is for them. There is something for everyone in this one."Fever Dreams is the sixth volume in the non-themed horror series of original stories, showcasing the very best short fiction that the genre has to offer, and edited by Mark Morris. This new anthology contains 20 original horro...

The #1 Relationship Book for CouplesYou love each other. So why does it still feel like something is missing?With more than 20 million copies sold, The 5 Love Languages® is the bestselling relationship book that has helped millions of couples communicate better, connect more deeply, and build stronger relationships. It's also the book many wish they'd found years earlier. Why? Because it works.

Celebrate the thirtieth anniversary of the Newbery Honor–winning survival novel Hatchet with a pocket-sized edition perfect for travelers to take along on their own adventures. This special anniversary edition includes a new introduction and commentary by author Gary Paulsen, pen-and-ink illustrations by Drew Willis, and a water resistant cover. Hatchet has also been nominated as one of America’s best-loved novels by PBS’s The Great American Read.

An eye-opening, myth-shattering examination of what makes us fat, from acclaimed science writer Gary Taubes.In his New York Times best seller, Good Calories, Bad Calories, Taubes argued that our diet’s overemphasis on certain kinds of carbohydrates—not fats and not simply excess calories—has led directly to the obesity epidemic we face today. The result of thorough research, keen insight, and unassailable common sense, Good Calories, Bad Calo...

The anniversary edition of the #1 New York Times bestseller beloved by millions of readers, with a new introduction by the author, a contribution from Maya Angelou, and a foreword by Oprah Winfrey.The Seat of the Soul encourages you become the authority in your own life. It will change the way you see the world, interact with other people, and understand your own actions and motivations. Beginning with evolution, Gary Zukav takes you on a penetrat...

**NEW YORK TIMES BESTSELLER • WINNER OF BOLLINGER EVERYMAN WODEHOUSE PRIZE FOR COMIC FICTIONThe uncannily prescient (and deliciously dark) tale of America’s dysfunctional near future—and the timeless, tender feelings that just might bring us back from the brink, by the bestselling author of The SensualistNAMED ONE OF THE BEST BOOKS OF THE YEAR BYThe New York Times • The Washington Post • The Boston Globe • San Francisco Chronicle • The Seattle T...

Shortlisted for the Scotiabank Giller Prize and nominated for the Governor-General's Award for Literature, a hilarious, swashbuckling yet powerful tale of pirates, buried treasure and a search for the Fountain of Youth, told in the ribald, philosophical voice of a 500-year-old Jewish parrot.Set in the years around 1492, Yiddish for Pirates recounts the compelling story of Moishe, a Bar Mitzvah boy who leaves home to join a ship's crew, where he meets Aaron...

Tulsa Police Department Sergeant Jonathan Thorpe finds his wife and young daughter slain in their home. Frustrated by the department’s failure to solve the crime, Thorpe conducts his own covert investigation. As Cold Blue opens, a brutal interrogation leads to a shocking revelation that requires Thorpe to mete out a very personal form of justice. A lone man against a rogue group, Thorpe sets off a controversy that brings the FBI into the midst of the city’s police department. And the FBI’s...

In Hatchet, 13-year-old Brian Robeson learned to survive alone in the Canadian wilderness, armed only with his hatchet. Finally, as millions of readers know, he was rescued at the end of the summer. But what if Brian hadn't been rescued? What if he had been left to face his deadliest enemy--winter?Gary Paulsen raises the stakes for survival in this riveting and inspiring story as one boy confronts the ultimate test and the ultimate adventure.