First published in 1888 for beginners, Model Engine-Making is a fascinating and comprehensive guide to building your first steam engine. While steam is no longer “the most important power of the day,” this book remains a fascinating in-depth resource for those with either a theoretical or practical interest in building and using small steam engines. Included within this book are over 100 detailed diagrams drawn by the author to illustrate the process of building each engine, inclu...

This comprehensive, unified text on the principles and practice of clinical trials presents a detailed account of how to conduct the trials. It describes the design, analysis, and interpretation of clinical trials in a non-technical manner and provides a general perspective on their historical development, current status, and future strategy. Features examples derived from the author's personal experience.

A psychiatrist takes a critical look at this SSRI and newer medications that are among the most frequently prescribed drugs in America.Prozac. Millions of Americans are on it. And just about everyone else is wondering if they should be on it, too. The claims of the pro‑Prozac chorus are enticing: that it can cure everything from depression (the only disorder for which Prozac was originally approved) to fear of public speaking, PMS, obesity, shyness, migraine, and ba...

Part of Osprey Modelling 22: Modelling the Sturmgeschütz III, a detailed, step-by-step guide to modelling a 1/35-scale StuG III.The Sturmgeschütz III proved to be one of the more significant German AFVs of World War II, with over 9,000 being produced up until April 1945. Originally designed in the late 1930s as a self-propelled infantry support gun, its role became more diverse throughout the war and it served as a tank hunter and in front-line Panzer comp...

A definitive guide to the art of painting and finishing models, with step-by-step instructions and photographs.Although many modellers can master the basic techniques of construction, it is with the painting and finishing of their kits that many begin to struggle. It is this skill that gives the model its distinctive look and feel and separates the good model from the truly great one. This title presents a detailed, step-by-step approach to addressing the difficult...

In recent years, the fabrication of nanomaterials and exploration of their properties have attracted the attention of various scientific disciplines such as biology, physics, chemistry, and engineering. Although nanoparticulate systems are of significant interest in various scientific and technological areas, there is little known about the safety of these nanoscale objects. It has now been established that the surfaces of nanoparticles are immediately covered by biomolecules (e.g. protein...

A step-by-step guide to building six different varieties of the Tiger tank – one of the most popular armour modeling subjects of all time.Probably the most famous tank of the World War II, the Tiger I was originally conceived in 1941 in response to the German Army's experience in fighting British tanks and anti-tank guns in Western Europe and the North African desert. It has proved to be one of the most popular modelling subjects of all time, with a vast and ever-i...

The Messerschmitt Bf 110 was undoubtedly one of the most significant aircraft of World War II.Despite suffering setbacks in the summer of 1940 at the hands of the RAF, it continued to be used effectively in other theatres and roles until the last days of the war, particularly as a night fighter against RAF Bomber Command's strategic bombing campaign over the Reich.This volume shows you how to correct and convert basic 1/48-scale kits of the Bf 110 into many...

In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the...

Solve the machinery failure problems costing you time and money with this classic, comprehensive guide to analysis and troubleshooting - Provides detailed, complete and accurate information on anticipating risk of component failure and avoiding equipment downtime - Includes numerous photographs of failed parts to ensure you are familiar with the visual evidence you need to recognize - Covers proven approaches to failure definition and offers failure identification and analysis methods that...

This book provides a comprehensive overview of metabonomics and gut microbiota research from molecular analysis to population-based global health considerations. The topics include the discussion of the applications in relation to metabonomics and gut microbiota in nutritional research, in health and disease and a review of future therapeutical, nutraceutical and clinical applications. It also examines the translatability of systems biology approaches into applied clinical research and to ...

Sleep Deprivation, Stimulant Medications, and Cognition provides a review, synthesis and analysis of the scientific literature concerning stimulant medications and neurobehavioral performance, with an emphasis on critically evaluating the practical utility of these agents for maintaining cognitive performance and alertness in sleep-deprived (but otherwise healthy) individuals. The book explores the nature of sleep loss-induced cognitive deficits, neurophysiologic basis of these deficits, r...