The recent explosion of neuroscience techniques has proved to be game changing in terms of understanding the healthy brain, and in the development of neuropsychiatric treatments. One of the key techniques available to us is functional magnetic resonance imaging (fMRI), which allows us to examine the human brain non-invasively, and observe brain activity in real time. Through fMRI, we are beginning to build a deeper understanding of our thoughts, motivations, and behaviours. Recent reports ...

From a world-renowned leader in neuroscience, a provocative, enthralling journey into the depths of the human mind.Where do our thoughts come from? How do we make choices and trust our judgments? What is the role of the unconscious? Can we manipulate our dreams? In this mind-bending international bestseller, award-winning neuroscientist Mariano Sigman explores the complex answers to these and many other age-old questions.Over the course of his 20-year career ...

Novel Psychoactive Substances: Classification, Pharmacology and Toxicology provides readers with background on the classification, detection, supply and availability of novel psychoactive substances, otherwise known as "legal highs." This book also covers individual classes of novel psychoactive substances that have recently emerged onto the recreational drug scene and provides an overview of the pharmacology of the substance followed by a discussion of the acute and chronic harm or toxici...

The Physiology of Synapses covers the considerable advances in understanding the complex physiology of synapses. This book is divided into 16 chapters that emphasize the mechanism of synaptic transmission. The first chapters describe the structural and physiological features of chemically transmitting synapses. The subsequent chapters deal with the excitatory postsynaptic responses to presynaptic impulse and the release of transmitter by presynaptic impulses. These topics are followed by d...

This classic text has been used in over 20 countries by advanced undergraduate and beginning graduate students in biophysics, physiology, medical physics, neuroscience, and biomedical engineering. It bridges the gap between an introductory physics course and the application of physics to the life and biomedical sciences.Extensively revised and updated, the fifth edition incorporates new developments at the interface between physics and biomedicine. New coverage includes cyclotrons,...

Ready to take your career to the next level? Find out everything you need to know about maximising your intellectual abilities with this practical guide.Human beings only use 10% of their brain capacity: this is a fact that most people are aware of, but few know what it really represents. Optimising our intellectual abilities allows us to learn and remember things more easily, make more effective decisions and grow both professionally and personally. This guide wil...

This book is intended for students of medicine, pharmacy and other biological disciplines, who want to have a working knowledge of the mechanisms of action, uses and adverse effects of drugs which modify the activity of neurotransmitters in the peripheral and central nervous systems. It is suitable for undergraduates and for post-graduates on taught higher degree courses and diplomas. New information and concepts have been incorporated into the text as appropriate, and references have been...

Human Motivation, originally published in 1987, offers a broad overview of theory and research from the perspective of a distinguished psychologist whose creative empirical studies of human motives span forty years. David McClelland describes methods for measuring motives, the development of motives out of natural incentives and the relationship of motives to emotions, to values and to performance under a variety of conditions. He examines four major motive systems - achievement, power, af...

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biolog...

This issue of Current Topics in Behavioral Neuroscience focuses on the neuropeptide orexin (hypocretin) and brings together scientists from around the world who will provide a timely discussion of how this peptide regulates behavior. This is a fast-moving field, and with the incorporation of novel technologies, new breakthroughs are likely to continue. For example, the use of optogenetic approaches has enabled the identification of the role of orexin-containing neurons in arousal ...

The basic thesis for this study was that the telencephalon is needed to make decisions in new situations. Subsidary hypotheses were that the telencephalon consists of: (a) a sensorimotor system which generates motor activity from sensory input and (b) a selection system which makes choices from possible motor programs. It was postulated that the selection system should fulfil the following requirements: be accessible for past and present events, have the capacity to process this informatio...

This thesis reports on a novel system for extracellular recordings of the activity of excitable cells, which relies on an organic, charge-modulated field-effect transistor (FET) called OCMFET. The book shows how, thanks to the intrinsic biocompatibility, lightness, and inexpensiveness of the material used, this new system is able to overcome several problems typical of of “classic” electronic and bioelectronic. It provides a full description of the system, together with a comprehensive rep...