The book is devoted to the neurosurgical management of spasticity. Starting with a chapter on the anatomical and physiological foundations of spasticity and a short history of its neurosurgical treatment, it describes the neurosurgical methods currently available. As management differs between adults and children, the book is also structured accordingly, including evaluation, decision-making, Intrathecal Baclofen Therapy (ITB), botulinum toxin therapy and surgery. Beyond ITB, the neurosurg...

PrefaceTurkish spine surgeons have been very productive for the last 20 years. Especially neurosurgeons have edited many textbooks on spine. However they were mostly in Turkish language and could not have international impact. This is one of the first English textbooks on spine written by Turkish authors and editors. The editors of this book are well known Tuskish neuro-spine surgeons who have been in administrative functions of Spine and Peripheral Nerve Section of the Turkish Neur...

The human skull has many functions. The largest component of the skull, the neurocranium, protects and insulates the brain. It comprises the dome-shaped vault or calvaria, obviously a protective structure, and the more complex cranial base, which gives the vault a massive foundation and also houses the organs of hearing, balance, and smell. The facial skeleton, or splanchnocranium, encloses the upper airway and the mouth. Chewing, the cQ-ordinated action ofthe jaws and teeth, is a function...

For this issue, Dr. Michael Lim of Johns Hopkins and Dr. Isaac Yang of UCSF team up to deliver a packed issue on the latest developments in Immunotherapy. The issue covers hot topics such as immunostimulants, Passive Antibody Mediated Immunotherapy, Clinical Applications of A Peptide Based Vaccine, Challenges for Clinical Design of Immunotherapy Trials, The EGFRv3 Peptide Vaccine, Stem Cell Therapy and Dendritic Cell Vaccines, Dendritic Glioma Fusion Vaccine, Adoptive Cellular Immunotherap...

This book provides the reader with a detailed update on the use of stereotactic radiosurgery (SRS) in patients with lesions of the brain and other parts of the body. The aim is not simply to explain the application of SRS and document its value with reference to the author's own clinical experiences and other published evidence, but also to contextualize the technology within a new strategic concept of cancer care. When embedded within an appropriate conceptual framework, technology become...

Cushing´s syndrome is a relatively rare clinical disorder that is associated with many co-morbidities such as systemic hypertension, diabetes, osteoporosis, impaired immune function and growth impairment in children, all of which severely reduce quality of life and life expectancy. Cushing’s Syndrome: Pathophysiology, Diagnosis and Treatment reviews the difficulties in distinguishing Cushing’s syndrome from these and other common conditions, such as central obesity, menstrual irregularity ...

The cerebrospinal fluid (CSF) is an invaluable diagnostic tool in clinical neurology, not only in the evaluation of inflammatory, degenerative, and malignant diseases of the nervous system, but also in the diagnosis of all forms of cerebral and subarachnoidal bleedings. The CSF can be easily obtained by lumbar puncture and a set of basic analyses can be conducted using relatively simple laboratory methods. By combining different CSF parameters, a wide range of diagnostic entities can be id...

The aim of the book is to describe the current approach to meningiomas on the basis of experience gained in the fields of histopathology, biology, radiology and surgery. The first section of the book deals with general diagnostic aspects. The typical histopathological features of meningiomas and the various abnormalities shown by imaging methods are discussed. The second section elucidates the growth pattern of meningiomas arising in various specific locat...

In 1981, the Norwegian physiologist and cyberneticist, Rune Aaslid, developed a device which made it possible to apply the transcranial Doppler sonographic technique in man. In 1983, Dr. Albrecht Harders took on the project of working out a clinically practicable method that would allow atraumatic measurements to be made of the blood flow velocity in the large branches ofthe circle of Willis. The technique has now become a competitor of the conventional methods of measuring the intracrania...

Hydatid disease, a zoonotic infection caused by a tapeworm of the genus Echinococcus, has been encountered in various organs in humans. In spite of all the advances in imaging techniques and therapeutic methods, hydatidosis of the central nervous system is still a life-threatening condition in infested areas of the world. This is the first comprehensive reference book on hydatidosis of the central nervous system. It is written and edited by leading international authorities from infested a...

This 16th volume of Advances in Neurosurgery contains a selection of pa pers presented at the 38th Annual Meeting of the German Society of Neurosurgery, held in Munster on 3-6 May 1987. The program committee had to choose these contributions from a total of 161 presentations. I am very much obliged to the members of the committee who contributed their experience and effort to the organization of the scientific pro gram: Prof. Dr. R.A. Frowein, Prof. Dr. W.J. Bock, Prof. Dr. E. Kazner, Prof...