Increasing specialisation in pathology reflects the progressive changes in medical practise. The advent of a specialist with a new interest in a hospital or clinic may present the pathologist with a need to extend his or her knowledge to be able to work closely with the clinical practi tioner in order to provide adequate clinical care. Some sub-specialisations are long established, such a one is neu ropathology. However, an exclusive specialist practise is generally con fined to neurosurgi...

In commissioning this volume of Current Topics in Pathology, the editor of the series, Prof. Sir Colin Berry, asked me to produce something "which is aimed at the general pathologist but from the point of view of the neuropathologist who knows what is not being done well". This was easier said than done. Many aspects of neuropathology are encountered only infrequently in general pathology and are best dealt with by re ferral of material to a specialist unit. Others need more extensive inve...

This new edition, like previous ones, offers a precise description of the anatomy of the human hippocampus based upon neurosurgical progress and the wealth of medical imaging methods available. The first part describes the fine structures of the hippocampus and is illustrated with new original figures. A survey is then provided of current concepts explaining the functions of the hippocampus, and the external and internal hippocampal vascularization is precisely described. The last and main...

It is well known that estrogen is "somehow” a protective hormone for various age-related disorders. This book provides a solid knowledge of estrogen’s neuroprotective activities in the brain with a special emphasis on neurodegenerative disorders such as Alzheimer’s Disease. The focus is (1) to describe the biochemical, molecular, and cellular basis of the protective activity of estrogen and (2) to transfer this knowledge into the hospitals by discussing preventive and therapeutic approache...

The current concept of dystonic movement connects the abnormal function of somatosensory pathways and somatosensory analyzers with the dystonic performance of motor action, which is based on the abnormality of sensorimotor integration. This concept is reflected not only in idiopathic dystonia, but also in secondary and symptomatic dystonias. This book will give a comprehensive account of the history of the terms dystonia and dystonic, the physiology of dystonic movement and the genetics an...

Peripheral nerve analysis is a challenging task for pathologists, given the advent of new diagnoses and techniques of analysis and the impact of molecular genetics. This book presents a simple, logical method for constructing a differential diagnosis based on pathology and clinical presentation. It also provides advice on the selection of ancillary molecular, immunohistochemical and genetic techniques to establish a definitive diagnosis. Clear, authoritative guidance is offered on diagnosi...

This book reviews the recent progress made in the prevention, diagnosis, and treatment of esophageal cancer. Epidemiology, molecular biology, pathology, staging, and prognosis are first discussed. The radiologic assessment of esophageal cancer and the role of endoscopy in diagnosis, staging, and management are then described. The principles of surgical resection, radiation therapy, and systemic chemotherapy for esophageal cancer are explained, and particular attention is paid to the multid...

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Digital pathology has experienced exponential growth, in terms of its technology and applications, since its inception just over a decade ago. Though it has yet to be approved for primary diagnostics, its values as a teaching tool, facilitator of second opinions and quality assurance reviews and research are becoming, if not already, undeniable. It also offers the hope of providing pathology consultant and educational services to under-served areas, including regions of the world that coul...

This book is dedicated to Dr. Philip A. Schwartzkroin. The book has a novel format because it is not intended to be a set of reviews. Instead, it is an effort to explore important topics in the epilepsy research field. Because articles are written by leaders in the field who have years of experience and individuals with diverse expertise, articles are likely to have a long-lasting impact and be relevant for both epileptologists and neuroscientists. Authors address topics that are important...