Evidence-based medicine has shown for many years that homozygous mutations of the HFE gene H63D are by no means negligible. Not only can it provoke, usually after a second hit, rather mild classical hemochromatosis, but it can also cause numerous other disorders of iron metabolism, such as Oslo-Syndrome. The latter is a severe disease which leads to multiple organ damages and is - for reasons that remain in the dark - not as known as Wilson's disease which is a very similar syndrome caused...

Naltrexone is an opiate antagonist drug developed in the 1970s and approved by the FDA in 1984 for opiate and drug abuse treatment. When used at much lower doses in an off-label protocol referred to as low dose naltrexone (LDN), the drug has been shown to halt disease progression in Crohn's disease and certain cancers, to reduce symptoms in multiple sclerosis and autism, and to improve numerous autoimmune and neurodegenerative conditions, including Parkinson's disease and amyotrophic later...

Study the latest research findings by international experts!This comprehensive volume presents state-of-the-art scientific research on the therapeutic uses of cannabis and its derivatives. All too often, discussions of the potential medical uses of this substance are distorted by political considerations that have no place in a medical debate. Cannabis and Cannabinoids: Pharmacology, Toxicology, and Therapeutic Potential features fair, equitable discussion of this emerging and controversia...

It's no surprise that marijuana has healing powers, but whether or not using it to treat common ailments should be legalized continues to be a hot topic of debate among government leaders and medical practitioners alike. Marijuana comes from the cannabis plant, an herb whose leaves can be extracted and used as a recreational drug, allowing users to feel a euphoric high. But the cannabis plant has many non-psychoactive properties as well. Cannabidiol, also known as CBD is a substance extrac...

Neurofibromatosis is a disease that disturbs the proper growth of the cells of your nervous system. It is genetic, which means that you may suffer from it because one or both of your parents had this disease. If you get affected with neurofibromatosis, you have an increased risk of being affected with other kinds of tumors related to nervous system, such as spinal cord tumors. Cancer is caused by neurofibromatosis tumors in very rare cases. So far, there is no definite cure for neurofibrom...

Derived from the National Parkinson Foundation's website column "Ask the Doctor" this book answers frequently asked questions about Parkinson's disease in depth. Useful for caregivers, family members, and individuals living with PD, Ask the Doctor About Parkinson's Disease informs, empowers, and reassures readers with solutions and advice to their most pressing concerns. No topic is too simple or too complex. Written by two of the most recognized experts in the field, Drs. Okun an...

Oslo Syndrome (in research still known as H63D Syndrome) is a worldwide health problem in the field of iron metabolism disorders. After scientists from all over the world joined together in 2019 to form the H63D Syndrome Consortium, the consensus paper "H63D Syndrome" was adopted at a meeting in Oslo in December 2019. On the occasion of the 2022 conference the syndrome was renamed Oslo Syndrome for clinical settings. It is available in bookshops for a symbolic price. Also free of charge di...

This text presents difficult management issues surrounding women with epilepsy in a unique format. The Editors provide several controversial cases in adolescence, pre-conception, pregnancy and menopause with invited experts offering their differing opinions. The Editors compare the clinical approaches and build a consensus based on the best available evidence. Professionals charged with managing this challenging patient group will be given insights on providing the best possible care based...

A comprehensive review of the scientific literature on the possible benefits of CBD, describing findings from both preclinical and human clinical studies.CBD (cannabidiol), a nonintoxicating compound derived from the cannabis plant, can be found in products ranging from lotion and smoothies to chewable gummies and pet treats. It’s been promoted—but not always scientifically validated—as a treatment for medical conditions including psychosis, anxiety, pain, and even...

The 2e of Escherichia coli is a unique, comprehensive analysis of the biology and molecular mechanisms that enable this ubiquitous organism to thrive. Leading investigators in the field discuss the molecular basis of E. coli pathogenesis followed by chapters on genomics and evolution. Detailed descriptions of distinct strains reveal the molecular pathogenesis of each and the causes of intestinal and extra-intestinal infections in humans. This work concludes with a presentation of virulence...

Genetic and Metabolic Disease in Pediatrics is a compendium of papers that discusses the problems of inborn diseases in terms of homeostasis. One paper traces "backward" from the disease phenotype to discover and investigate the gene, as well as moves "forward" from mutation in DNA to discover phenotypes or proteins connected with the disease. Specific genes are assigned to particular places (loci) on chromosomes that can manifest the presence or type of disease. Another paper examines a c...

This practical text provides a clinical overview of the etiology, diagnosis and treatment for fibromyalgia. Current evidence-based treatments and guidelines are emphasized along with lifestyle modification suggestions for the patient. Also included is a review of current literature, research and emerging developments on this prevalent pain syndrome. A range of healthcare specialties, including pain management, rheumatology, neurology, internal medicine and family practice, will find this c...