This book gathers the proceedings of the I-ESA’18 Conference, which was organised by the Fraunhofer IPK, on behalf of the European Virtual Laboratory for Enterprise Interoperability (INTEROP-VLab) and the DFI, and was held in Berlin, Germany in March 2018. It presents contributions ranging from academic research and case studies, to industrial and administrative experiences with interoperability that show how, in a globalised market scenario – where the ability to cooperate with other orga...