In the vibrant maze of Indian academia, where brilliance meets relentless hurdles, The Great Indian Academic Adventure takes readers on a journey through the drama, comedy, and occasional moments of genius that define university life. Packed with sharp humor and biting sarcasm, these tales explore the daily struggles of juggling research, teaching, and administration—all while facing the constant pressure to "publish or perish".From coffeefueled night owls to young academics discove...

Genome Analysis: Principles and Methods provides recent and advanced information about genome analysis approaches and techniques to study and annotate the structure and function of the genome. It is a compendium of important topics such as NGS analysis, genome fragmentation and assembly, metagenomics, cloning and expression, physical marker analysis, transcriptome data analysis, sequence alignment and comparison, evolutionary analysis, SNP analysis, genome-based disease diagnosis and thera...

The Three Functional States of Proteins explores how structured proteins, intrinsically disordered proteins, and phase separated proteins contribute to the complexity of cellular life, and offers insights into their roles in both health and disease. It discusses the latest research findings and highlight groundbreaking discoveries and innovative methodologies used to study these protein states.Traditionally, the different states of proteins have been defined based on their structures and f...

This book describes recent important advancements in protein folding dynamics and stability research, as well as explaining fundamentals and examining potential methodological approaches in protein science. In vitro, in silico, and in vivo method based research of how the stability and folding of proteins help regulate the cellular dynamics and impact cell function that are crucial in explaining various physiological and pathological processes. This book offers a comprehensive coverage on ...

Advanced Spectroscopic Methods to Study Biomolecular Structure and Dynamics presents the latest emerging technologies in spectroscopy and advances in established spectroscopic methods. The book presents a guide to research methods in biomolecular spectroscopy, providing comprehensive coverage of developments in the spectroscopic techniques used to study protein structure and dynamics. Seventeen chapters from leading researchers cover key aspects of spectroscopic methods, with each chapter ...

Advances in Protein Molecular and Structural Biology Methods offers a complete overview of the latest tools and methods applicable to the study of proteins at the molecular and structural level. The book begins with sections exploring tools to optimize recombinant protein expression and biophysical techniques such as fluorescence spectroscopy, NMR, mass spectrometry, cryo-electron microscopy, and X-ray crystallography. It then moves towards computational approaches, considering structural ...

This book provides an overview of the essential characteristics and clinical applications of therapeutic proteins against human diseases, including cancers, immune disorders, infections, and other diseases. It presents the latest advancements in protein engineering techniques for producing desirable therapeutic proteins. The book also covers the strategies used to formulate and deliver systemic therapeutic proteins, approved protein therapeutics and their targets, and pharmacogenetic bioma...

This book discusses a broad range of basic and advanced topics in the field of protein structure, function, folding, flexibility, and dynamics. Starting with a basic introduction to protein purification, estimation, storage, and its effect on the protein structure, function, and dynamics, it also discusses various experimental and computational structure determination approaches; the importance of molecular interactions and water in protein stability, folding and dynamics; kinetic and ther...

Frontiers in Computational Chemistry, originally published by Bentham and now distributed by Elsevier, presents the latest research findings and methods in the diverse field of computational chemistry, focusing on molecular modeling techniques used in drug discovery and the drug development process. This includes computer-aided molecular design, drug discovery and development, lead generation, lead optimization, database management, computer and molecular graphics, and the development of n...

This authoritative book on MALDI MS, now finally available in its second edition and edited by one of its inventors, gives an in-depth description of the many different applications, along with a detailed discussion of the technology itself.Thoroughly updated and expanded, with contributions from key players in the field, this unique book provides a comprehensive overview of MALDI MS along with itspossibilities and limitations.The initial chapters deal with the technol...

IT IS TIME FOR A NEW THEORY OF EVOLUTION BASED ON GENOMICS, NOT GUESSESIn 2011, James A. Shapiro's Evolution: A View from the 21st Century proposed a revolutionary paradigm for understanding biological evolution: natural genetic engineering, not random accidents, produce genome change. In the 21st-century view, organisms are active participants in the evolutionary process.Since then, climate change and multiple crises in infectious disease have given new ur...

For almost a decade, quantitative NMR spectroscopy (qNMR) has been established as valuable tool in drug analysis. In all disciplines, i. e. drug identification, impurity profiling and assay, qNMR can be utilized. Separation techniques such as high performance liquid chromatography, gas chromatography, super fluid chromatography and capillary electrophoresis techniques, govern the purity evaluation of drugs. However, these techniques are not always able to solve the analytical problems ofte...